Detailed information of TA system TA106734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 6802778..6803349
• Replicon: chromosome
• Accession: NZ_CP029823
• Organism: Streptomyces malaysiensis strain DSM 4137

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: DNK48_RS28335
• Protein ID: WP_079257839.1
• Coordinates: 6802975..6803349 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1P8XVF0
• Locus tag: DNK48_RS28330
• Protein ID: WP_069863663.1
• Coordinates: 6802778..6802975 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNK48_RS28310	6798180..6799085	+	906	WP_069863657.1	LysR family transcriptional regulator	-
DNK48_RS28315	6799256..6799825	+	570	WP_079257842.1	cysteine dioxygenase family protein	-
DNK48_RS28320	6799828..6800943	+	1116	WP_167460021.1	putative sulfate exporter family transporter	-
DNK48_RS28325	6801251..6802744	+	1494	WP_099013914.1	MFS transporter	-
DNK48_RS28330	6802778..6802975	+	198	WP_069863663.1	Arc family DNA-binding protein	Antitoxin
DNK48_RS28335	6802975..6803349	+	375	WP_079257839.1	Fic family protein	Toxin
DNK48_RS28340	6803461..6805257	+	1797	WP_079152962.1	DEAD/DEAH box helicase	-
DNK48_RS28345	6806159..6806800	+	642	WP_069863676.1	helix-turn-helix domain-containing protein	-
DNK48_RS28350	6806943..6807728	+	786	WP_069863678.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (11-80)

Antitoxin

• Arc-like DNA binding domain (4-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14001.81 Da
• Isoelectric Point: 4.7465

>T106734 WP_079257839.1 NZ_CP029823:6802975-6803349 [Streptomyces malaysiensis]
MHYLTLPELLNLAERLGESEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESSARNHALVDGNKRLSWYATWVFL
HINGHPLHADFDVDEAERFVLSVCQGELDVAKIAEGLTRFTERM

Nucleotide

• Length: 375 bp

>T106734 NZ_CP029823:6802975-6803349 [Streptomyces malaysiensis]
ATGCACTACCTCACGCTGCCCGAGCTGCTGAACCTCGCCGAGCGTCTCGGGGAGAGCGAAGTGCGCGACTACGGGCTGCT
GGAGTCCGCGCTGGCCCGTCCGCAGGCGAGTGTGTTCGGGCAGGACGCCTACCCGGACGTGTGGCAGAAGGCCGCTGCGC
TGATGGAGTCGTCGGCTCGCAACCACGCCTTGGTGGACGGCAACAAGCGGCTCTCCTGGTATGCGACCTGGGTCTTCCTC
CACATCAATGGGCATCCGCTGCACGCGGACTTCGACGTCGACGAGGCCGAGCGCTTCGTGCTGAGCGTCTGCCAGGGCGA
GCTGGACGTGGCGAAGATCGCGGAGGGGCTGACCCGGTTCACGGAAAGAATGTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7439.31 Da
• Isoelectric Point: 5.6033

>AT106734 WP_069863663.1 NZ_CP029823:6802778-6802975 [Streptomyces malaysiensis]
MAALNLRFTDEELDALRKRAEAEGRSMQSFAHDAVMAAINEHSRRFDEAADHVLRVSEELNRRLA

Nucleotide

• Length: 198 bp

>AT106734 NZ_CP029823:6802778-6802975 [Streptomyces malaysiensis]
ATGGCCGCGCTGAATCTACGTTTTACGGACGAAGAGCTCGACGCCTTGCGCAAGCGCGCGGAGGCGGAGGGCCGGAGCAT
GCAGTCGTTCGCCCACGACGCGGTGATGGCGGCGATCAATGAGCACTCCCGGCGGTTCGACGAGGCCGCCGACCATGTGT
TGCGGGTGAGCGAAGAGCTCAACCGGAGGCTCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1P8XVF0