106730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1382355..1383463 Replicon chromosome
Accession NZ_CP029804
Organism Erysipelothrix rhusiopathiae strain ML101

Toxin (Protein)


Gene name MNTss Uniprot ID A0A2I4SCC6
Locus tag DM789_RS06860 Protein ID WP_062810426.1
Coordinates 1382355..1383224 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag DM789_RS06865 Protein ID WP_002303393.1
Coordinates 1383239..1383463 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM789_RS06820 1378045..1378452 - 408 WP_072387101.1 WYL domain-containing protein -
DM789_RS06830 1378425..1378997 - 573 WP_001079938.1 HTH domain-containing protein -
DM789_RS06840 1379273..1380067 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
DM789_RS06845 1380160..1380702 - 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
DM789_RS06850 1380699..1381607 - 909 WP_001255864.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
DM789_RS06855 1381640..1382374 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
DM789_RS06860 1382355..1383224 - 870 WP_062810426.1 nucleotidyltransferase domain-containing protein Toxin
DM789_RS06865 1383239..1383463 - 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
DM789_RS06870 1383606..1384427 - 822 Protein_1309 recombinase zinc beta ribbon domain-containing protein -
DM789_RS06875 1385115..1385918 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
DM789_RS06880 1385972..1387456 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
DM789_RS06885 1387899..1388462 - 564 Protein_1312 recombinase zinc beta ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32793.31 Da        Isoelectric Point: 4.6575

>T106730 WP_062810426.1 NZ_CP029804:c1383224-1382355 [Erysipelothrix rhusiopathiae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

>T106730 NZ_CP029804:c1383224-1382355 [Erysipelothrix rhusiopathiae]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATTGTATTAGGGGGCTC
ACGTGCAAGAAGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAGTTGGATGATGAGAATAGAAACAACCTTGTTGTACCTCCCGGAGCGTGGGGTGATTGG
GTTAATGGCGGTGGATGGTTAGTTATAAACGGGTGTCATGTTGACTTGATATTACGTGATATAAAACGGGTGGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCTATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGCAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGACATGACCGAGAAACTTTATAATGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT106730 WP_002303393.1 NZ_CP029804:c1383463-1383239 [Erysipelothrix rhusiopathiae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp

>AT106730 NZ_CP029804:c1383463-1383239 [Erysipelothrix rhusiopathiae]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCTATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGATGAAATAAAAATATCTAACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I4SCC6

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References