Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 442106..442742 Replicon chromosome
Accession NZ_CP029797
Organism Paraliobacillus zengyii strain X-1125

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DM447_RS02325 Protein ID WP_112182627.1
Coordinates 442392..442742 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag DM447_RS02320 Protein ID WP_112179726.1
Coordinates 442106..442387 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM447_RS02300 437643..438011 + 369 WP_112179722.1 holo-ACP synthase -
DM447_RS02305 438079..439590 + 1512 WP_112179723.1 NAD(P)H-hydrate dehydratase -
DM447_RS02310 439644..440663 + 1020 WP_112179724.1 outer membrane lipoprotein carrier protein LolA -
DM447_RS02315 440828..441943 + 1116 WP_112179725.1 alanine racemase -
DM447_RS02320 442106..442387 + 282 WP_112179726.1 antitoxin Antitoxin
DM447_RS02325 442392..442742 + 351 WP_112182627.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DM447_RS02330 442949..443818 + 870 WP_112179727.1 RsbT co-antagonist protein RsbRA -
DM447_RS02335 443815..444180 + 366 WP_198663162.1 STAS domain-containing protein -
DM447_RS02340 444184..444603 + 420 WP_112179729.1 anti-sigma regulatory factor -
DM447_RS02345 444604..445617 + 1014 WP_112179730.1 PP2C family protein-serine/threonine phosphatase -
DM447_RS02350 445670..446005 + 336 WP_112179731.1 STAS domain-containing protein -
DM447_RS02355 446005..446481 + 477 WP_112179732.1 anti-sigma B factor RsbW -
DM447_RS02360 446453..447244 + 792 WP_112179733.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12952.07 Da        Isoelectric Point: 7.0141

>T106728 WP_112182627.1 NZ_CP029797:442392-442742 [Paraliobacillus zengyii]
MIVKRGEVYFADLSPVVGSEQGGVRPVLILQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITQLDNNMMEKIDKALEISLGLADF

Download         Length: 351 bp

>T106728 NZ_CP029797:442392-442742 [Paraliobacillus zengyii]
TTGATTGTAAAAAGAGGCGAAGTTTATTTCGCCGATCTTTCTCCTGTCGTTGGATCAGAGCAGGGCGGGGTACGCCCGGT
ATTGATCCTACAAAATAATATAGGTAATCGTTTTAGTCCTACGGTTATCGTTGCTGCCATTACCGCACAAATTCAAAAAG
CTAAATTGCCGACGCATGTCGAAATTGATGCAAAGAAATACGGTTTTGAACGTGACTCTGTTATTTTATTAGAGCAGATT
AGAACGATAGATAAACAGCGATTAACAGACAAAATAACGCAACTAGATAATAACATGATGGAAAAAATTGATAAAGCATT
AGAAATCAGTTTAGGTCTAGCAGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10888.42 Da        Isoelectric Point: 5.2390

>AT106728 WP_112179726.1 NZ_CP029797:442106-442387 [Paraliobacillus zengyii]
MVLSENAQEIVVRLPKNLLNEVDRLMKNENSDLNEFIYQATKSYLREKKKRHIRESMQRGYMEMAKINLNIASEAFQAEE
EAENTLERLVSGV

Download         Length: 282 bp

>AT106728 NZ_CP029797:442106-442387 [Paraliobacillus zengyii]
ATGGTTTTGTCAGAGAACGCACAAGAAATTGTTGTTCGATTACCTAAGAATCTGCTTAATGAGGTGGACCGTTTAATGAA
GAATGAGAACAGTGATCTGAATGAATTTATTTATCAGGCAACTAAATCGTATTTACGAGAGAAGAAAAAAAGACATATTC
GAGAATCCATGCAAAGAGGCTATATGGAAATGGCTAAAATTAATTTAAATATTGCTTCAGAAGCTTTTCAAGCTGAAGAG
GAGGCAGAAAACACCCTTGAGCGCTTAGTGAGTGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References