Detailed information of TA system TA106726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5327297..5327822
• Replicon: chromosome
• Accession: NZ_CP029788
• Organism: Streptomyces actuosus strain ATCC 25421

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DMT42_RS25135
• Protein ID: WP_110630116.1
• Coordinates: 5327297..5327560 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DMT42_RS25140
• Protein ID: WP_110630117.1
• Coordinates: 5327553..5327822 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMT42_RS25115	5323086..5324102	+	1017	WP_110630113.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
DMT42_RS25120	5324153..5324896	+	744	WP_110630114.1	ROK family protein	-
DMT42_RS25125	5324953..5325345	-	393	WP_110637037.1	hypothetical protein	-
DMT42_RS25130	5326124..5327212	+	1089	WP_110630115.1	redox-regulated ATPase YchF	-
DMT42_RS25135	5327297..5327560	-	264	WP_110630116.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DMT42_RS25140	5327553..5327822	-	270	WP_110630117.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DMT42_RS25145	5327996..5328469	-	474	WP_110630118.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-59)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10028.43 Da
• Isoelectric Point: 8.5041

>T106726 WP_110630116.1 NZ_CP029788:c5327560-5327297 [Streptomyces actuosus]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDYRVIYTIDNGELVVWAVHVGH
RSTVYDS

Nucleotide

• Length: 264 bp

>T106726 NZ_CP029788:c5327560-5327297 [Streptomyces actuosus]
GTGAGTGAGTACCGAACCGTCTTCCGACCCGAGGCCCAGGCCGAACTTCGGAAGATCCCTCGCGACATGGCCCTGCGCAT
CCTGGCCAAGCTGACCGAGCTGGAGAGCGACCCGCTGGGGTTCAACACCACGGCCCTCGTCTCCCAGCCCGACCGGCGCC
GCCTACGGGTGGGCGACTACCGCGTGATCTACACGATCGACAACGGTGAGCTGGTGGTGTGGGCCGTGCACGTCGGGCAT
CGCTCCACCGTCTACGACAGCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10318.78 Da
• Isoelectric Point: 4.7777

>AT106726 WP_110630117.1 NZ_CP029788:c5327822-5327553 [Streptomyces actuosus]
MTEPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANRAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT106726 NZ_CP029788:c5327822-5327553 [Streptomyces actuosus]
ATGACAGAACCGCTGCCCATAGAGTCCATCCGCGATGTCCGGGCGCACCTGGCCGAGGTCGTGGAGCGGGCCGACCGCGA
CGACGTACCGACGGTGATCACGCGCCGGGGCAAGCAGGTGGCTGCCGTGGTGTCCATCGAAGTGCTCCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAATCGAGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACCCTGGCGCGCGGTGAGTGA