Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4394324..4394958 Replicon chromosome
Accession NZ_CP029788
Organism Streptomyces actuosus strain ATCC 25421

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DMT42_RS20695 Protein ID WP_110629376.1
Coordinates 4394324..4394746 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DMT42_RS20700 Protein ID WP_110629377.1
Coordinates 4394743..4394958 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMT42_RS20680 4390416..4390934 - 519 WP_110636797.1 MarR family transcriptional regulator -
DMT42_RS20685 4391320..4392657 + 1338 WP_110629374.1 MFS transporter -
DMT42_RS20690 4392654..4394132 - 1479 WP_110629375.1 alpha/beta hydrolase -
DMT42_RS20695 4394324..4394746 - 423 WP_110629376.1 PIN domain nuclease Toxin
DMT42_RS20700 4394743..4394958 - 216 WP_110629377.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DMT42_RS20710 4395669..4396244 + 576 WP_110629378.1 dCTP deaminase -
DMT42_RS20715 4396253..4396750 + 498 WP_110636804.1 phosphoribosyltransferase -
DMT42_RS20720 4396820..4397830 - 1011 WP_110629379.1 YIP1 family protein -
DMT42_RS20725 4397917..4398351 - 435 WP_110629380.1 Lrp/AsnC family transcriptional regulator -
DMT42_RS20730 4398450..4399391 + 942 WP_110636806.1 SMP-30/gluconolactonase/LRE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-46)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15299.19 Da        Isoelectric Point: 4.8835

>T106725 WP_110629376.1 NZ_CP029788:c4394746-4394324 [Streptomyces actuosus]
VNGAQYLIDTSALARMLRGDAEQYGWDQAAAAGLIATCPVTELEFFHSARSAADRAQGIEDLRLIFGWVPVDDRAYDRAW
RVQELLTQRAQHRSAGAVDLVVAATAELQGLTLLHRDRDFECIAAVTGQALQWYGPAAGK

Download         Length: 423 bp

>T106725 NZ_CP029788:c4394746-4394324 [Streptomyces actuosus]
GTGAACGGCGCGCAGTACCTGATCGACACGAGTGCGCTCGCGCGCATGCTGCGCGGTGACGCCGAGCAGTACGGCTGGGA
CCAGGCGGCGGCCGCCGGGCTCATCGCCACCTGTCCCGTCACCGAGCTGGAGTTCTTCCACAGCGCGCGTTCCGCTGCCG
ACCGCGCACAAGGCATCGAGGACCTGCGTCTGATCTTCGGCTGGGTGCCGGTCGACGACCGCGCCTACGACCGTGCTTGG
CGGGTCCAGGAGCTCCTCACCCAGCGCGCACAGCACCGCAGTGCCGGAGCCGTCGATCTCGTGGTGGCCGCCACGGCCGA
GCTGCAGGGACTCACGCTGCTGCACCGTGACCGGGACTTCGAGTGCATCGCCGCCGTCACCGGCCAGGCACTCCAGTGGT
ACGGGCCCGCAGCCGGCAAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7946.96 Da        Isoelectric Point: 6.3273

>AT106725 WP_110629377.1 NZ_CP029788:c4394958-4394743 [Streptomyces actuosus]
VSRTVIDLDDQLLADVAKALGTSTKKETVNTALREVLENRRRALALARLRASAEEGAFDLDLFEDKGNYRR

Download         Length: 216 bp

>AT106725 NZ_CP029788:c4394958-4394743 [Streptomyces actuosus]
GTGAGTCGGACAGTGATCGACCTCGATGATCAGCTGCTGGCGGACGTGGCCAAGGCCCTTGGCACCAGCACCAAGAAGGA
GACGGTCAACACCGCGCTGCGCGAGGTGCTGGAGAACCGGCGGCGGGCACTGGCGCTCGCCCGTCTGCGGGCCTCGGCCG
AAGAGGGCGCCTTCGACCTCGACCTCTTCGAGGACAAGGGGAACTACCGTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References