Detailed information of TA system TA106719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2209566..2210080
• Replicon: chromosome
• Accession: NZ_CP029751
• Organism: Staphylococcus aureus strain Smith

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: CFC57_RS11410
• Protein ID: WP_000581796.1
• Coordinates: 2209566..2209775 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: W8UW13
• Locus tag: CFC57_RS11415
• Protein ID: WP_000138932.1
• Coordinates: 2209787..2210080 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFC57_RS11390	2205071..2206429	-	1359	WP_000611460.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
CFC57_RS11395	2206444..2207514	-	1071	WP_000159641.1	D-alanine--D-alanine ligase	-
CFC57_RS11400	2207832..2209034	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
CFC57_RS11405	2209301..2209438	-	138	WP_000828354.1	hypothetical protein	-
CFC57_RS11410	2209566..2209775	-	210	WP_000581796.1	heavy-metal-associated domain-containing protein	Toxin
CFC57_RS11415	2209787..2210080	-	294	WP_000138932.1	copper-sensing transcriptional repressor CsoR	Antitoxin
CFC57_RS11420	2210246..2211730	+	1485	WP_000571549.1	cardiolipin synthase	-
CFC57_RS11425	2211758..2212405	+	648	WP_001187632.1	HD domain-containing protein	-
CFC57_RS11430	2213270..2214142	-	873	WP_000725802.1	membrane protein insertase YidC	-
CFC57_RS11435	2214228..2214869	-	642	WP_000483087.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7859.77 Da
• Isoelectric Point: 4.1008

>T106719 WP_000581796.1 NZ_CP029751:c2209775-2209566 [Staphylococcus aureus]
MIHQNTIYTSGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T106719 NZ_CP029751:c2209775-2209566 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACATCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11197.82 Da
• Isoelectric Point: 6.2243

>AT106719 WP_000138932.1 NZ_CP029751:c2210080-2209787 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT106719 NZ_CP029751:c2210080-2209787 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: W8UW13