Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 881222..881699 Replicon chromosome
Accession NZ_CP029751
Organism Staphylococcus aureus strain Smith

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CFC57_RS04530 Protein ID WP_000052076.1
Coordinates 881222..881410 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CFC57_RS04535 Protein ID WP_001059690.1
Coordinates 881439..881699 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFC57_RS04500 877210..877731 + 522 WP_000824475.1 hypothetical protein -
CFC57_RS04505 878072..878758 + 687 WP_001806511.1 thermonuclease family protein -
CFC57_RS04510 879115..879315 + 201 WP_001059082.1 cold-shock protein -
CFC57_RS04515 879813..880031 - 219 WP_000005882.1 hypothetical protein -
CFC57_RS04520 880105..880377 - 273 WP_001004400.1 hypothetical protein -
CFC57_RS04525 880465..881034 - 570 WP_001106648.1 hypothetical protein -
CFC57_RS04530 881222..881410 - 189 WP_000052076.1 hypothetical protein Toxin
CFC57_RS04535 881439..881699 - 261 WP_001059690.1 hypothetical protein Antitoxin
CFC57_RS04540 882039..882242 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CFC57_RS04545 882239..882475 - 237 WP_000368687.1 hypothetical protein -
CFC57_RS04550 882701..883282 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CFC57_RS04555 883355..883972 - 618 WP_000255555.1 LysE/ArgO family amino acid transporter -
CFC57_RS04560 884128..884622 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
CFC57_RS04565 885020..885442 - 423 WP_000974462.1 organic hydroperoxide resistance protein -
CFC57_RS04570 885590..886306 + 717 WP_000951568.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 875853..909287 33434


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106712 WP_000052076.1 NZ_CP029751:c881410-881222 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106712 NZ_CP029751:c881410-881222 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106712 WP_001059690.1 NZ_CP029751:c881699-881439 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106712 NZ_CP029751:c881699-881439 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATAAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References