Detailed information of TA system TA106707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2039440..2040064
• Replicon: chromosome
• Accession: NZ_CP029749
• Organism: Streptococcus agalactiae strain PLGBS13

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: DLM82_RS10685
• Protein ID: WP_000253103.1
• Coordinates: 2039440..2039787 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: DLM82_RS10690
• Protein ID: WP_000543070.1
• Coordinates: 2039777..2040064 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLM82_RS10665	2035155..2035511	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
DLM82_RS10670	2035578..2037896	-	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
DLM82_RS10675	2038035..2038574	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
DLM82_RS10680	2038660..2038956	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
DLM82_RS10685	2039440..2039787	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DLM82_RS10690	2039777..2040064	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DLM82_RS10695	2040133..2040510	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
DLM82_RS10700	2040485..2040637	-	153	Protein_1958	DUF1492 domain-containing protein	-
DLM82_RS10705	2040644..2041132	-	489	WP_000891151.1	hypothetical protein	-
DLM82_RS10710	2041205..2041762	-	558	WP_001258765.1	hypothetical protein	-
DLM82_RS10715	2041920..2042093	-	174	WP_000694573.1	hypothetical protein	-
DLM82_RS10720	2042090..2042347	-	258	WP_001069293.1	hypothetical protein	-
DLM82_RS10725	2042640..2044034	-	1395	WP_000656430.1	hypothetical protein	-
DLM82_RS10730	2044046..2044903	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T106707 WP_000253103.1 NZ_CP029749:c2039787-2039440 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T106707 NZ_CP029749:c2039787-2039440 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT106707 WP_000543070.1 NZ_CP029749:c2040064-2039777 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT106707 NZ_CP029749:c2040064-2039777 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5