Detailed information of TA system TA106693

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4446897..4447695
• Replicon: chromosome
• Accession: NZ_CP029747
• Organism: Escherichia coli strain 2016C-3878

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: BEN53_RS22705
• Protein ID: WP_061092894.1
• Coordinates: 4447318..4447695 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: BEN53_RS22700
• Protein ID: WP_061092893.1
• Coordinates: 4446897..4447271 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BEN53_RS22665	4442562..4443242	+	681	WP_001282921.1	WYL domain-containing protein	-
BEN53_RS22670	4443390..4444067	+	678	WP_001097302.1	hypothetical protein	-
BEN53_RS22675	4444073..4444306	+	234	WP_001278293.1	DUF905 family protein	-
BEN53_RS22680	4444396..4445214	+	819	WP_001175165.1	DUF945 domain-containing protein	-
BEN53_RS22685	4445480..4445959	+	480	WP_000706978.1	antirestriction protein	-
BEN53_RS22690	4445974..4446450	+	477	WP_001186188.1	RadC family protein	-
BEN53_RS22695	4446513..4446734	+	222	WP_061092892.1	DUF987 domain-containing protein	-
BEN53_RS22700	4446897..4447271	+	375	WP_061092893.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BEN53_RS22705	4447318..4447695	+	378	WP_061092894.1	TA system toxin CbtA family protein	Toxin
BEN53_RS22710	4447692..4448180	+	489	WP_061092895.1	hypothetical protein	-
BEN53_RS22715	4448192..4448389	+	198	WP_012908799.1	DUF957 domain-containing protein	-
BEN53_RS22720	4448474..4449316	+	843	WP_061092922.1	DUF4942 domain-containing protein	-
BEN53_RS22730	4449584..4449730	+	147	WP_001328030.1	hypothetical protein	-
BEN53_RS22735	4450114..4451298	+	1185	WP_001172864.1	sugar efflux transporter	-
BEN53_RS22740	4451409..4452332	+	924	WP_000535959.1	carboxylate/amino acid/amine transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14196.15 Da
• Isoelectric Point: 7.8045

>T106693 WP_061092894.1 NZ_CP029747:4447318-4447695 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T106693 NZ_CP029747:4447318-4447695 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13752.53 Da
• Isoelectric Point: 6.5924

>AT106693 WP_061092893.1 NZ_CP029747:4446897-4447271 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNHLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS

Nucleotide

• Length: 375 bp

>AT106693 NZ_CP029747:4446897-4447271 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCACCTGCATTACCTTGCCGACCGCGCGGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA