Detailed information of TA system TA106658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4376115..4376640
• Replicon: chromosome
• Accession: NZ_CP029746
• Organism: Serratia marcescens strain AR_0122

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AM369_RS20750
• Protein ID: WP_033646666.1
• Coordinates: 4376115..4376399 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: AM369_RS20755
• Protein ID: WP_004928423.1
• Coordinates: 4376389..4376640 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM369_RS20725	4371375..4372508	+	1134	WP_033637812.1	putrescine ABC transporter ATP-binding subunit PotG	-
AM369_RS20730	4372533..4373495	+	963	WP_033646669.1	putrescine ABC transporter permease PotH	-
AM369_RS20735	4373492..4374337	+	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
AM369_RS20740	4374442..4374921	+	480	WP_048321404.1	YbjO family protein	-
AM369_RS20745	4374991..4376118	+	1128	WP_033646667.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
AM369_RS20750	4376115..4376399	-	285	WP_033646666.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM369_RS20755	4376389..4376640	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
AM369_RS20760	4376742..4377476	-	735	WP_033637816.1	arginine ABC transporter substrate-binding protein	-
AM369_RS20765	4377676..4378344	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
AM369_RS20770	4378344..4379060	-	717	WP_033646665.1	arginine ABC transporter permease ArtQ	-
AM369_RS20775	4379070..4379801	-	732	WP_039566746.1	arginine ABC transporter substrate-binding protein	-
AM369_RS20780	4379834..4380562	-	729	WP_038884338.1	arginine ABC transporter ATP-binding protein ArtP	-
AM369_RS20785	4380827..4381369	-	543	WP_033637821.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10797.98 Da
• Isoelectric Point: 10.7537

>T106658 WP_033646666.1 NZ_CP029746:c4376399-4376115 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETKIVVLVLSVGK
REHSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T106658 NZ_CP029746:c4376399-4376115 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCAGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGAAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACATTCAGCGGCTTATACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT106658 WP_004928423.1 NZ_CP029746:c4376640-4376389 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT106658 NZ_CP029746:c4376640-4376389 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1