Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3749432..3750053 Replicon chromosome
Accession NZ_CP029746
Organism Serratia marcescens strain AR_0122

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag AM369_RS17675 Protein ID WP_004940313.1
Coordinates 3749432..3749635 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag AM369_RS17680 Protein ID WP_004940312.1
Coordinates 3749685..3750053 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM369_RS17650 3745223..3745669 + 447 WP_039566985.1 type II secretion system protein M -
AM369_RS17655 3745706..3746521 + 816 WP_048321316.1 A24 family peptidase -
AM369_RS17660 3746518..3746880 - 363 WP_033647278.1 type II secretion system pilot lipoprotein GspS -
AM369_RS17665 3747134..3748564 + 1431 WP_043146738.1 N-acetylglucosamine-binding protein GbpA -
AM369_RS17670 3748617..3749135 + 519 WP_047568991.1 cytochrome b/b6 domain-containing protein -
AM369_RS17675 3749432..3749635 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
AM369_RS17680 3749685..3750053 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
AM369_RS17685 3750212..3750565 - 354 WP_033647274.1 hypothetical protein -
AM369_RS17690 3750973..3751686 + 714 WP_048321317.1 ABC transporter ATP-binding protein -
AM369_RS17695 3751683..3752540 + 858 WP_033637343.1 metal ABC transporter permease -
AM369_RS17700 3752566..3753444 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
AM369_RS17705 3753551..3753691 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
AM369_RS17710 3753704..3753958 - 255 WP_048321318.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T106656 WP_004940313.1 NZ_CP029746:c3749635-3749432 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T106656 NZ_CP029746:c3749635-3749432 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT106656 WP_004940312.1 NZ_CP029746:c3750053-3749685 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT106656 NZ_CP029746:c3750053-3749685 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References