Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2683030..2683631 Replicon chromosome
Accession NZ_CP029746
Organism Serratia marcescens strain AR_0122

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag AM369_RS12615 Protein ID WP_033649548.1
Coordinates 2683030..2683410 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag AM369_RS12620 Protein ID WP_004933932.1
Coordinates 2683410..2683631 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM369_RS12590 2678283..2679563 + 1281 WP_033649550.1 DUF3748 domain-containing protein -
AM369_RS12595 2679594..2679941 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
AM369_RS12600 2680252..2680665 + 414 WP_004933919.1 heat shock chaperone IbpA -
AM369_RS12605 2680766..2681194 + 429 WP_004933922.1 heat shock chaperone IbpB -
AM369_RS12610 2681361..2683019 + 1659 WP_033649549.1 putative transporter -
AM369_RS12615 2683030..2683410 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
AM369_RS12620 2683410..2683631 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
AM369_RS12625 2683706..2684956 - 1251 WP_033649547.1 valine--pyruvate transaminase -
AM369_RS12630 2685092..2687155 - 2064 WP_048321223.1 alpha-amylase -
AM369_RS24600 2687352..2687504 + 153 WP_019455508.1 hypothetical protein -
AM369_RS12635 2687506..2688483 - 978 WP_033636542.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T106652 WP_033649548.1 NZ_CP029746:c2683410-2683030 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T106652 NZ_CP029746:c2683410-2683030 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGTATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT106652 WP_004933932.1 NZ_CP029746:c2683631-2683410 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT106652 NZ_CP029746:c2683631-2683410 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References