Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1981120..1981715 Replicon chromosome
Accession NZ_CP029746
Organism Serratia marcescens strain AR_0122

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AM369_RS09365 Protein ID WP_072071906.1
Coordinates 1981461..1981715 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM369_RS09360 Protein ID WP_033633573.1
Coordinates 1981120..1981461 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM369_RS09345 1977311..1978126 - 816 WP_048321965.1 GPO family capsid scaffolding protein -
AM369_RS09350 1978269..1980041 + 1773 WP_033632041.1 terminase ATPase subunit family protein -
AM369_RS09355 1980041..1981075 + 1035 WP_048321966.1 phage portal protein -
AM369_RS09360 1981120..1981461 - 342 WP_033633573.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM369_RS09365 1981461..1981715 - 255 WP_072071906.1 type II toxin-antitoxin system HicA family toxin Toxin
AM369_RS09370 1982100..1983182 - 1083 WP_072071907.1 restriction endonuclease -
AM369_RS09375 1983179..1984975 - 1797 WP_072071908.1 type I restriction-modification system subunit M -
AM369_RS09380 1985136..1985348 - 213 WP_072071909.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-Ic - 1946923..1998752 51829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9526.00 Da        Isoelectric Point: 11.1073

>T106651 WP_072071906.1 NZ_CP029746:c1981715-1981461 [Serratia marcescens]
MNKRHQKTLSDVFTRPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

>T106651 NZ_CP029746:c1981715-1981461 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTACCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12399.90 Da        Isoelectric Point: 4.5789

>AT106651 WP_033633573.1 NZ_CP029746:c1981461-1981120 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 342 bp

>AT106651 NZ_CP029746:c1981461-1981120 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCTATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References