Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1313291..1313947 Replicon chromosome
Accession NZ_CP029746
Organism Serratia marcescens strain AR_0122

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AM369_RS06230 Protein ID WP_033648839.1
Coordinates 1313291..1313680 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AM369_RS06235 Protein ID WP_033648840.1
Coordinates 1313684..1313947 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM369_RS06215 1309758..1311188 + 1431 WP_043147820.1 multidrug transporter subunit MdtD -
AM369_RS06220 1311185..1312567 + 1383 WP_033635541.1 two-component system sensor histidine kinase BaeS -
AM369_RS06225 1312567..1313283 + 717 WP_033635542.1 two-component system response regulator BaeR -
AM369_RS06230 1313291..1313680 - 390 WP_033648839.1 type II toxin-antitoxin system VapC family toxin Toxin
AM369_RS06235 1313684..1313947 - 264 WP_033648840.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AM369_RS06240 1314287..1314625 + 339 WP_033648841.1 YegP family protein -
AM369_RS06245 1314806..1316158 + 1353 WP_033654556.1 tRNA 5-hydroxyuridine modification protein YegQ -
AM369_RS06250 1316622..1317527 + 906 WP_033635546.1 lipid kinase YegS -
AM369_RS06255 1317817..1318866 + 1050 WP_033635553.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14277.50 Da        Isoelectric Point: 7.8786

>T106648 WP_033648839.1 NZ_CP029746:c1313680-1313291 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSVVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T106648 NZ_CP029746:c1313680-1313291 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCGTGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCGCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10032.29 Da        Isoelectric Point: 4.6702

>AT106648 WP_033648840.1 NZ_CP029746:c1313947-1313684 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDADRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT106648 NZ_CP029746:c1313947-1313684 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATGCGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCACAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References