106639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 591089..591594 Replicon chromosome
Accession NZ_CP029745
Organism Pseudomonas aeruginosa strain AR_0110

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag AM489_RS02865 Protein ID WP_003083773.1
Coordinates 591313..591594 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag AM489_RS02860 Protein ID WP_003083775.1
Coordinates 591089..591316 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM489_RS02835 586108..587601 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
AM489_RS02840 587770..589197 + 1428 WP_003083784.1 GABA permease -
AM489_RS02845 589279..589620 - 342 WP_003101229.1 alkylphosphonate utilization protein -
AM489_RS02850 589693..590193 - 501 WP_003162763.1 LEA type 2 family protein -
AM489_RS02855 590294..590914 + 621 WP_003101226.1 hypothetical protein -
AM489_RS02860 591089..591316 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
AM489_RS02865 591313..591594 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
AM489_RS02870 591894..592802 + 909 WP_003083769.1 LysR family transcriptional regulator -
AM489_RS02875 592834..593220 - 387 WP_003083767.1 aegerolysin family protein -
AM489_RS02880 593424..594158 - 735 WP_003117208.1 GntR family transcriptional regulator -
AM489_RS02885 594259..594945 - 687 WP_003083762.1 FadR family transcriptional regulator -
AM489_RS02890 594994..596343 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T106639 WP_003083773.1 NZ_CP029745:591313-591594 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T106639 NZ_CP029745:591313-591594 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT106639 WP_003083775.1 NZ_CP029745:591089-591316 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT106639 NZ_CP029745:591089-591316 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References