Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 78461..78996 Replicon plasmid unnamed1
Accession NZ_CP029742
Organism Escherichia coli strain AR_0085

Toxin (Protein)


Gene name relE Uniprot ID A0A0D8WEY8
Locus tag AM464_RS27760 Protein ID WP_032353555.1
Coordinates 78709..78996 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WHE0
Locus tag AM464_RS27755 Protein ID WP_045145550.1
Coordinates 78461..78712 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM464_RS27700 74034..74234 - 201 Protein_84 DUF1449 family protein -
AM464_RS27710 74501..75166 - 666 WP_000154146.1 hypothetical protein -
AM464_RS27715 75307..75948 - 642 WP_021547665.1 hypothetical protein -
AM464_RS27735 76644..77516 + 873 WP_181869882.1 incFII family plasmid replication initiator RepA -
AM464_RS30100 78207..78374 + 168 WP_065898644.1 hypothetical protein -
AM464_RS27755 78461..78712 + 252 WP_045145550.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AM464_RS27760 78709..78996 + 288 WP_032353555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM464_RS30105 79006..79293 + 288 WP_045145547.1 hypothetical protein -
AM464_RS27775 80453..80899 + 447 WP_021560313.1 serine acetyltransferase -
AM464_RS27780 81179..81772 - 594 WP_032353553.1 proQ/FINO family protein -
AM464_RS27800 82626..83813 - 1188 WP_045145541.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..139740 139740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11114.16 Da        Isoelectric Point: 10.6261

>T106629 WP_032353555.1 NZ_CP029742:78709-78996 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T106629 NZ_CP029742:78709-78996 [Escherichia coli]
ATGACTTATACGGTTAAATTCAGGGATGATGCACTGAAAGAATGGCTCAGACTGGATAAGGCCATTCAGCAGCAGTTCGC
AAAAAAACTAAAAAAATGCAGTGAAAATCCTCATATAGCCTCTGCAAAACTACGTGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9219.48 Da        Isoelectric Point: 4.1789

>AT106629 WP_045145550.1 NZ_CP029742:78461-78712 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHYVDLD
SYL

Download         Length: 252 bp

>AT106629 NZ_CP029742:78461-78712 [Escherichia coli]
ATGCCCAGTATAATTTTGTCTGACACCAGTGCAAGCGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGTTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCAGCTGAGCTCTATGAAAGGATGC
TTGATGCCCTGGATGACCAGGAGCTGGTGAAACTGGTTACTGAGCGCAGCAGTCAGCCTCTGCATTATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8WEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WHE0

References