Detailed information of TA system TA106608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3101572..3102386
• Replicon: chromosome
• Accession: NZ_CP029741
• Organism: Escherichia coli strain AR_0085

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: AM464_RS16165
• Protein ID: WP_001054376.1
• Coordinates: 3102129..3102386 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: AM464_RS16160
• Protein ID: WP_001309181.1
• Coordinates: 3101572..3102117 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM464_RS16135	3097263..3098576	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
AM464_RS16140	3098588..3098866	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AM464_RS16145	3098863..3099984	-	1122	WP_000010829.1	M42 family metallopeptidase	-
AM464_RS30285	3100229..3100345	-	117	Protein_2955	VOC family protein	-
AM464_RS16150	3100383..3100601	-	219	Protein_2956	hypothetical protein	-
AM464_RS16155	3100770..3101516	-	747	WP_110844142.1	class I SAM-dependent methyltransferase	-
AM464_RS16160	3101572..3102117	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
AM464_RS16165	3102129..3102386	-	258	WP_001054376.1	hypothetical protein	Toxin
AM464_RS16175	3102763..3103008	-	246	Protein_2960	GNAT family N-acetyltransferase	-
AM464_RS16185	3103124..3104364	+	1241	Protein_2961	helicase YjhR	-
AM464_RS16190	3104947..3105927	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
AM464_RS16195	3105992..3107098	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T106608 WP_001054376.1 NZ_CP029741:c3102386-3102129 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T106608 NZ_CP029741:c3102386-3102129 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT106608 WP_001309181.1 NZ_CP029741:c3102117-3101572 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT106608 NZ_CP029741:c3102117-3101572 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8