Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4141116..4141773 Replicon chromosome
Accession NZ_CP029738
Organism Klebsiella pneumoniae strain AR_0087

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM466_RS21005 Protein ID WP_002916310.1
Coordinates 4141363..4141773 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM466_RS21000 Protein ID WP_002916312.1
Coordinates 4141116..4141382 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM466_RS20975 4136272..4137705 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
AM466_RS20980 4137824..4138552 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AM466_RS20985 4138602..4138913 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AM466_RS20990 4139077..4139736 + 660 WP_002916317.1 hemolysin III family protein -
AM466_RS20995 4139887..4140870 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
AM466_RS21000 4141116..4141382 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM466_RS21005 4141363..4141773 + 411 WP_002916310.1 protein YgfX Toxin
AM466_RS21010 4141780..4142301 - 522 WP_004144730.1 flavodoxin FldB -
AM466_RS21015 4142402..4143298 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM466_RS21020 4143321..4144034 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM466_RS21025 4144040..4145773 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T106583 WP_002916310.1 NZ_CP029738:4141363-4141773 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T106583 NZ_CP029738:4141363-4141773 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT106583 WP_002916312.1 NZ_CP029738:4141116-4141382 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT106583 NZ_CP029738:4141116-4141382 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References