Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2717933..2718449 Replicon chromosome
Accession NZ_CP029738
Organism Klebsiella pneumoniae strain AR_0087

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AM466_RS13770 Protein ID WP_002886902.1
Coordinates 2717933..2718217 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM466_RS13775 Protein ID WP_002886901.1
Coordinates 2718207..2718449 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM466_RS13750 2713349..2713657 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
AM466_RS29380 2713742..2713915 + 174 WP_032410138.1 hypothetical protein -
AM466_RS13755 2713918..2714661 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
AM466_RS13760 2715018..2717156 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AM466_RS13765 2717465..2717929 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM466_RS13770 2717933..2718217 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM466_RS13775 2718207..2718449 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM466_RS13780 2718527..2720437 - 1911 WP_009486549.1 BglG family transcription antiterminator -
AM466_RS13785 2720460..2721614 - 1155 WP_023302389.1 lactonase family protein -
AM466_RS13790 2721681..2722421 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T106578 WP_002886902.1 NZ_CP029738:c2718217-2717933 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T106578 NZ_CP029738:c2718217-2717933 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT106578 WP_002886901.1 NZ_CP029738:c2718449-2718207 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT106578 NZ_CP029738:c2718449-2718207 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References