Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4303222..4303867 Replicon chromosome
Accession NZ_CP029736
Organism Providencia rettgeri strain AR_0082

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag AM461_RS19915 Protein ID WP_004905417.1
Coordinates 4303664..4303867 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6G6PGA8
Locus tag AM461_RS19910 Protein ID WP_004914480.1
Coordinates 4303222..4303590 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM461_RS19885 4298434..4299195 - 762 WP_004914471.1 DNA polymerase III subunit epsilon -
AM461_RS19890 4299250..4299720 + 471 WP_004914473.1 ribonuclease HI -
AM461_RS19895 4299717..4300451 - 735 WP_109911903.1 methyltransferase domain-containing protein -
AM461_RS19900 4300492..4301247 + 756 WP_004914477.1 hydroxyacylglutathione hydrolase -
AM461_RS19905 4301329..4302699 + 1371 WP_109911902.1 murein transglycosylase D -
AM461_RS19910 4303222..4303590 + 369 WP_004914480.1 Hha toxicity modulator TomB Antitoxin
AM461_RS19915 4303664..4303867 + 204 WP_004905417.1 hemolysin expression modulator Hha Toxin
AM461_RS19925 4304429..4304887 - 459 WP_004914482.1 YbaY family lipoprotein -
AM461_RS19930 4305127..4305996 + 870 WP_109911901.1 acyl-CoA thioesterase II -
AM461_RS19935 4306135..4307415 - 1281 WP_109911900.1 ammonium transporter AmtB -
AM461_RS19940 4307426..4307764 - 339 WP_004905421.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T106573 WP_004905417.1 NZ_CP029736:4303664-4303867 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T106573 NZ_CP029736:4303664-4303867 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACAACAATTGAAACTCTTGAGCGTGTCATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTATTCAGCTGCAGATCACCGCTTAGCTGAGCTCACAATGAATAAGC
TTTATGATAAAATTCCAGCTTCTGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.06 Da        Isoelectric Point: 4.3849

>AT106573 WP_004914480.1 NZ_CP029736:4303222-4303590 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNQSLVTVLDDDLKCLTSKT

Download         Length: 369 bp

>AT106573 NZ_CP029736:4303222-4303590 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACACGATATAGCAGAACTAAAATACTTATGTAATAGCCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTTATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATATCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAGTATCTC
GATGAGACCTACGATTTATTCGGCAGCCCAGTCATCACGCTCAGTGAAATTATAGACTGGGAAGCAATGAATCAGAGTCT
TGTCACTGTGTTGGATGATGACCTAAAGTGTCTAACCAGCAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PGA8

References