Detailed information of TA system TA106571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2770913..2771829
• Replicon: chromosome
• Accession: NZ_CP029736
• Organism: Providencia rettgeri strain AR_0082

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AM461_RS12825
• Protein ID: WP_109912200.1
• Coordinates: 2770913..2771371 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6G6PJY5
• Locus tag: AM461_RS12830
• Protein ID: WP_004910826.1
• Coordinates: 2771368..2771829 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM461_RS12800	2766448..2767914	+	1467	WP_110731924.1	AMP nucleosidase	-
AM461_RS12805	2767895..2768458	+	564	WP_080641505.1	GNAT family N-acetyltransferase	-
AM461_RS12810	2768489..2768911	+	423	WP_004910820.1	helix-turn-helix domain-containing protein	-
AM461_RS12815	2769017..2769976	+	960	WP_109912198.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
AM461_RS12820	2770022..2770912	+	891	WP_109912199.1	LysR family transcriptional regulator	-
AM461_RS12825	2770913..2771371	-	459	WP_109912200.1	RES domain-containing protein	Toxin
AM461_RS12830	2771368..2771829	-	462	WP_004910826.1	DUF2384 domain-containing protein	Antitoxin
AM461_RS12835	2771918..2772385	-	468	WP_109912201.1	DUF1456 family protein	-
AM461_RS12840	2772577..2772891	-	315	WP_004910828.1	AzlD domain-containing protein	-
AM461_RS12845	2772888..2773589	-	702	WP_004910829.1	AzlC family ABC transporter permease	-
AM461_RS12850	2773648..2774502	-	855	WP_004910830.1	AraC family transcriptional regulator	-
AM461_RS12855	2774988..2775629	+	642	WP_004910832.1	leucine efflux protein LeuE	-
AM461_RS12860	2775922..2776395	+	474	WP_110731925.1	NUDIX domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-146)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (99-150)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17178.73 Da
• Isoelectric Point: 6.2048

>T106571 WP_109912200.1 NZ_CP029736:c2771371-2770913 [Providencia rettgeri]
MILYRLVKSSFIHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDLLLNQFSLLSIDINDRYVMKLSLD
HLPTDWQQDPAPTSTMDIGTTWLNNQDSLVLLIPSCIIPYEYNAIINPLHPQFQKAIHTVKPLDFSVDSRLA

Nucleotide

• Length: 459 bp

>T106571 NZ_CP029736:c2771371-2770913 [Providencia rettgeri]
ATGATTTTGTATCGATTGGTTAAATCCAGTTTTATTCACGATGCATGGTCTGGTCAAGGAGCCATGCTCTACGGTGGGCG
TTGGAATCATAAAGGAACTCCCGCTGTTTATACTTCAACCAGTATTTCATTAGCCACCCTTGAAATACTCGTTCACATCA
ATCAAGACTTACTATTAAACCAGTTCAGTTTGCTATCCATCGATATCAATGACAGGTACGTGATGAAACTGTCGTTAGAC
CACCTTCCAACAGATTGGCAGCAAGACCCAGCGCCAACTTCTACCATGGATATTGGTACTACATGGCTAAATAACCAAGA
TAGCTTAGTATTATTAATTCCCTCTTGTATTATTCCCTACGAATACAATGCAATTATTAACCCGTTGCACCCGCAATTTC
AAAAAGCCATACATACTGTTAAACCGCTGGATTTTAGTGTTGACTCACGCTTAGCATAG

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17060.54 Da
• Isoelectric Point: 9.9140

>AT106571 WP_004910826.1 NZ_CP029736:c2771829-2771368 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAAGDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT106571 NZ_CP029736:c2771829-2771368 [Providencia rettgeri]
ATGAGAAACTATATCCCCACAACCCCACTTCAACCGACTGCTTCATCTTTTAAACCACTATGGCGCCATGTAGGGTTACC
TGCCGAACGTGGTATTGAATTGACCCACTTCTTACGCCAAGGGCTGTCTGTCTCTGTTTTAGACAATATCCAAGAATGGT
CAGGGATGAGTAAAACTGAATTATTACGGATATCCGGCATTAATGAACGCAATATTGCTCGTCGCAAAAATGCAGGCCAA
CCCCTCAATGCTGATGAAAGCGAACGAATTGCTCGTCTAGTACGCGTATTCGATGCGGCAGTGCGTTTATTTAATGGAGA
TAAACATGCAGCAGGTGATTGGCTTAATCACCCCGTTAAAGGGTTAGGCCATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGTGGAGCCATTGAGGTAATTGATTTGATTGGCCGCATTGAGCATGGTGTGTTTTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A6G6PJY5