106560

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4774775..4775395 Replicon chromosome
Accession NZ_CP029727
Organism Citrobacter sp. CRE-46 strain AR_0157

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AN232_RS23985 Protein ID WP_002892050.1
Coordinates 4775177..4775395 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag AN232_RS23980 Protein ID WP_003021733.1
Coordinates 4774775..4775149 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN232_RS23970 4769922..4771115 + 1194 WP_038638348.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AN232_RS23975 4771138..4774287 + 3150 WP_038638345.1 multidrug efflux RND transporter permease subunit -
AN232_RS23980 4774775..4775149 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
AN232_RS23985 4775177..4775395 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AN232_RS23990 4775581..4776132 + 552 WP_110498628.1 maltose O-acetyltransferase -
AN232_RS23995 4776249..4776719 + 471 WP_069323967.1 YlaC family protein -
AN232_RS24000 4776793..4776933 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
AN232_RS24005 4776935..4777195 - 261 WP_038638331.1 type B 50S ribosomal protein L31 -
AN232_RS24010 4777384..4778937 + 1554 WP_038638327.1 EAL domain-containing protein -
AN232_RS24015 4778989..4779342 - 354 WP_038638323.1 DUF1428 family protein -
AN232_RS24020 4779407..4780036 - 630 WP_038638321.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T106560 WP_002892050.1 NZ_CP029727:4775177-4775395 [Citrobacter sp. CRE-46]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T106560 NZ_CP029727:4775177-4775395 [Citrobacter sp. CRE-46]
ATGTCTGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGCTGCCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCGGATCACCGTCTTGCTGAAT
TGACCATGAATAAGCTCTACGACAAGATTCCAACTTCCGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT106560 WP_003021733.1 NZ_CP029727:4774775-4775149 [Citrobacter sp. CRE-46]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT106560 NZ_CP029727:4774775-4775149 [Citrobacter sp. CRE-46]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAACGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATTGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAATCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References