Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3635393..3636150 | Replicon | chromosome |
| Accession | NZ_CP029727 | ||
| Organism | Citrobacter sp. CRE-46 strain AR_0157 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | AN232_RS18045 | Protein ID | WP_110498072.1 |
| Coordinates | 3635668..3636150 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A2Z3X7E0 |
| Locus tag | AN232_RS18040 | Protein ID | WP_038640582.1 |
| Coordinates | 3635393..3635677 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AN232_RS18010 | 3630445..3630843 | - | 399 | WP_085048211.1 | potassium channel family protein | - |
| AN232_RS18015 | 3631055..3631693 | + | 639 | WP_110498069.1 | helix-turn-helix domain-containing protein | - |
| AN232_RS18020 | 3631855..3632169 | + | 315 | WP_085048213.1 | helix-turn-helix transcriptional regulator | - |
| AN232_RS18025 | 3632162..3633433 | + | 1272 | WP_110498070.1 | type II toxin-antitoxin system HipA family toxin | - |
| AN232_RS18030 | 3633471..3634838 | - | 1368 | WP_110498071.1 | glycoside hydrolase family 10 protein | - |
| AN232_RS18035 | 3634851..3635138 | - | 288 | WP_079224212.1 | VF530 family protein | - |
| AN232_RS18040 | 3635393..3635677 | + | 285 | WP_038640582.1 | DUF1778 domain-containing protein | Antitoxin |
| AN232_RS18045 | 3635668..3636150 | + | 483 | WP_110498072.1 | GNAT family N-acetyltransferase | Toxin |
| AN232_RS18050 | 3636173..3636484 | - | 312 | Protein_3393 | helix-turn-helix transcriptional regulator | - |
| AN232_RS18055 | 3636712..3637773 | + | 1062 | Protein_3394 | ISNCY family transposase | - |
| AN232_RS18060 | 3637784..3637933 | - | 150 | Protein_3395 | transposase | - |
| AN232_RS18065 | 3637997..3638320 | + | 324 | Protein_3396 | ISNCY family transposase | - |
| AN232_RS18070 | 3638581..3639375 | - | 795 | WP_110498074.1 | hypothetical protein | - |
| AN232_RS18075 | 3639356..3639880 | - | 525 | Protein_3398 | GNAT family N-acetyltransferase | - |
| AN232_RS18080 | 3639990..3640748 | + | 759 | WP_110498075.1 | trans-aconitate 2-methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3636712..3637779 | 1067 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17882.61 Da Isoelectric Point: 8.2691
>T106559 WP_110498072.1 NZ_CP029727:3635668-3636150 [Citrobacter sp. CRE-46]
MEINVTTPVLLTEGHDLQPFDCGNDVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDVCTQGHRFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI
MEINVTTPVLLTEGHDLQPFDCGNDVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDVCTQGHRFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI
Download Length: 483 bp
>T106559 NZ_CP029727:3635668-3636150 [Citrobacter sp. CRE-46]
ATGGAAATAAACGTCACGACACCGGTCTTGCTGACCGAAGGGCATGATCTCCAGCCATTTGATTGTGGTAATGACGTGTT
AAATGATTGGCTACGTCGGCGGGCGATTAAAAATCAGTACCTCAACGCATCGCGCACATTCGTCATTTGTCTTGAATCTA
CTCAGCGTGTTGTGGGTTACTATTCCATTGCAACCGGGTCCGTGAGCCATGCTGATTTAGGCCGTAGTTTACGTCAGAAT
ATGCCCGATCCGGTTCCGGTCGTTCTGCTGGGACGTCTTGCTGTTGATGTCTGTACTCAGGGGCATCGTTTCGGAAAATG
GCTACTTAATGATGCGGTACTGCGAATTTCCAACTTAGCCGATCAAGTGGGCATCAAAGCCATCATGGTACATGCTATTG
ATGGCAAAGCTCGGGCATTCTATGAGTATTTCGGCTTCGTTCAGTCTCCGATAGCAGCAAATACGTTGTTCTACAAAATT
TAG
ATGGAAATAAACGTCACGACACCGGTCTTGCTGACCGAAGGGCATGATCTCCAGCCATTTGATTGTGGTAATGACGTGTT
AAATGATTGGCTACGTCGGCGGGCGATTAAAAATCAGTACCTCAACGCATCGCGCACATTCGTCATTTGTCTTGAATCTA
CTCAGCGTGTTGTGGGTTACTATTCCATTGCAACCGGGTCCGTGAGCCATGCTGATTTAGGCCGTAGTTTACGTCAGAAT
ATGCCCGATCCGGTTCCGGTCGTTCTGCTGGGACGTCTTGCTGTTGATGTCTGTACTCAGGGGCATCGTTTCGGAAAATG
GCTACTTAATGATGCGGTACTGCGAATTTCCAACTTAGCCGATCAAGTGGGCATCAAAGCCATCATGGTACATGCTATTG
ATGGCAAAGCTCGGGCATTCTATGAGTATTTCGGCTTCGTTCAGTCTCCGATAGCAGCAAATACGTTGTTCTACAAAATT
TAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10998.45 Da Isoelectric Point: 7.0152
>AT106559 WP_038640582.1 NZ_CP029727:3635393-3635677 [Citrobacter sp. CRE-46]
MQSSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAPVQNV
EGRQRLMNVKPEWK
MQSSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAPVQNV
EGRQRLMNVKPEWK
Download Length: 285 bp
>AT106559 NZ_CP029727:3635393-3635677 [Citrobacter sp. CRE-46]
ATGCAAAGCAGCGCCCGTAAACCGACTCGTGATAAGCAAATTAATATCCGGGCTACTGATGAGGAACGTGCGGTAATTGA
CTACGCCGCAAGTTTGGTCAATAAAAACCGTACTGACTTCATCATTGAGAAGGCCGTGCATGAGGCCCAGAATATCATTT
TGGATCAACGAGTATTCGTCCTGGACGATGCCCGTTATCAGTCTTTCATTGAACAGCTTGAAGCACCTGTTCAGAACGTT
GAAGGGCGTCAACGCCTGATGAATGTGAAGCCCGAATGGAAATAA
ATGCAAAGCAGCGCCCGTAAACCGACTCGTGATAAGCAAATTAATATCCGGGCTACTGATGAGGAACGTGCGGTAATTGA
CTACGCCGCAAGTTTGGTCAATAAAAACCGTACTGACTTCATCATTGAGAAGGCCGTGCATGAGGCCCAGAATATCATTT
TGGATCAACGAGTATTCGTCCTGGACGATGCCCGTTATCAGTCTTTCATTGAACAGCTTGAAGCACCTGTTCAGAACGTT
GAAGGGCGTCAACGCCTGATGAATGTGAAGCCCGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|