106549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1754170..1754824 Replicon chromosome
Accession NZ_CP029727
Organism Citrobacter sp. CRE-46 strain AR_0157

Toxin (Protein)


Gene name cptA Uniprot ID A0A2Z3X2B8
Locus tag AN232_RS08875 Protein ID WP_038633481.1
Coordinates 1754417..1754824 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag AN232_RS08870 Protein ID WP_016154349.1
Coordinates 1754170..1754436 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN232_RS08840 1749372..1750805 - 1434 WP_038633498.1 6-phospho-beta-glucosidase BglA -
AN232_RS08845 1750926..1751654 - 729 WP_085048762.1 MurR/RpiR family transcriptional regulator -
AN232_RS08850 1751707..1752018 + 312 WP_085048763.1 N(4)-acetylcytidine aminohydrolase -
AN232_RS08855 1752182..1752841 + 660 WP_038633489.1 hemolysin III family protein -
AN232_RS08860 1752933..1753913 - 981 WP_085048764.1 tRNA-modifying protein YgfZ -
AN232_RS08870 1754170..1754436 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
AN232_RS08875 1754417..1754824 + 408 WP_038633481.1 protein YgfX Toxin
AN232_RS08880 1754925..1755446 - 522 WP_038633478.1 flavodoxin FldB -
AN232_RS08885 1755560..1756456 + 897 WP_038633475.1 site-specific tyrosine recombinase XerD -
AN232_RS08890 1756480..1757193 + 714 WP_061382414.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AN232_RS08895 1757199..1758932 + 1734 WP_110496909.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15944.81 Da        Isoelectric Point: 11.2845

>T106549 WP_038633481.1 NZ_CP029727:1754417-1754824 [Citrobacter sp. CRE-46]
VVQWQSDLRVSWRAQWLSLLVHGLVAVFILLMPWPLSYTPLWMVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIVSAPWMVKTGMMLRLRSDTGKRQHLWLAADSMDEAEWRDLRRLMLQQAKQG

Download         Length: 408 bp

>T106549 NZ_CP029727:1754417-1754824 [Citrobacter sp. CRE-46]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCGCAGTGGCTTTCGTTGCTCGTTCATGGGCTGGTCGCGGT
ATTTATTTTATTGATGCCCTGGCCTTTGAGCTACACCCCATTATGGATGGTTCTGCTCTCTCTGGTGGTGTTCGACAGCG
TACGCAGCCAACGTAGAATTAATGCCTGTCAGGGCGAGATTAGGCTGTTGATGGACGGCCGTCTGCGCTGGCAAGGGCAG
GAGTGGACTATCGTTAGCGCGCCCTGGATGGTCAAAACAGGCATGATGCTGCGTTTGCGTTCAGATACCGGGAAACGTCA
GCATTTGTGGCTAGCGGCAGACAGTATGGATGAGGCTGAGTGGCGAGATTTACGGCGGTTAATGCTGCAACAGGCGAAGC
AGGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT106549 WP_016154349.1 NZ_CP029727:1754170-1754436 [Citrobacter sp. CRE-46]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT106549 NZ_CP029727:1754170-1754436 [Citrobacter sp. CRE-46]
ATGGATATTAACAATAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCTATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGACGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTCAGTTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3X2B8

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References