Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 225776..226295 Replicon chromosome
Accession NZ_CP029727
Organism Citrobacter sp. CRE-46 strain AR_0157

Toxin (Protein)


Gene name relE Uniprot ID A0A2Z3WY74
Locus tag AN232_RS01135 Protein ID WP_038636706.1
Coordinates 225776..226057 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2Z3X2E3
Locus tag AN232_RS01140 Protein ID WP_038636704.1
Coordinates 226047..226295 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN232_RS01120 222778..223242 + 465 WP_110496139.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AN232_RS01125 223264..223785 - 522 WP_110496140.1 toxin-antitoxin system YwqK family antitoxin -
AN232_RS01130 223785..225749 - 1965 WP_110496141.1 type VI secretion system tip protein VgrG -
AN232_RS01135 225776..226057 - 282 WP_038636706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN232_RS01140 226047..226295 - 249 WP_038636704.1 plasmid stabilization protein Antitoxin
AN232_RS01145 226443..227078 - 636 WP_110496142.1 hypothetical protein -
AN232_RS01150 227104..229626 - 2523 WP_110496143.1 type VI secretion system ATPase TssH -
AN232_RS01155 229617..230561 - 945 WP_110496144.1 type VI secretion system baseplate subunit TssG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.76 Da        Isoelectric Point: 10.4466

>T106544 WP_038636706.1 NZ_CP029727:c226057-225776 [Citrobacter sp. CRE-46]
MTYSLEFLDIALKEWRKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Download         Length: 282 bp

>T106544 NZ_CP029727:c226057-225776 [Citrobacter sp. CRE-46]
ATGACCTATAGTCTGGAGTTTTTAGATATTGCGCTCAAGGAGTGGCGCAAACTTTCACCCACATTACGCGAGCAGTTCAA
AAAGAAGCTAGCGGAACGGCTAGAGAACCCTCATGTCCCTGCCGCCCGCCTGTCTGGCAAATTACACCGTTATAAAATCA
AGCTACGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCCGTGGGCAGA
CGTGATGGCGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8987.23 Da        Isoelectric Point: 4.5338

>AT106544 WP_038636704.1 NZ_CP029727:c226295-226047 [Citrobacter sp. CRE-46]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIQVSLN
DL

Download         Length: 249 bp

>AT106544 NZ_CP029727:c226295-226047 [Citrobacter sp. CRE-46]
ATGCCATTTCACATACTGACCAAAACCGCAGCCAGCATCACCGACCTGAAACGTAACCCGATGGGGACGGTTAACGCAGG
GGAAGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTCTATGCGTATTTGC
TGGAGCTGGCAGAAGATGCGGAGCTGAACCGTATCGCCGACGAACGTGAAGGTGGAAAGCGAATACAGGTGTCTTTAAAT
GACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3WY74

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3X2E3

References