Detailed information of TA system TA106541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3415755..3416454
• Replicon: chromosome
• Accession: NZ_CP029725
• Organism: Proteus mirabilis strain AR_0029

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: AM356_RS15825
• Protein ID: WP_004249093.1
• Coordinates: 3416068..3416454 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: AM356_RS15820
• Protein ID: WP_004246828.1
• Coordinates: 3415755..3416075 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM356_RS15790	3410883..3411158	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
AM356_RS15795	3411213..3411836	-	624	WP_004246821.1	guanylate kinase	-
AM356_RS15800	3412138..3412755	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
AM356_RS15805	3412892..3414178	+	1287	WP_049256516.1	DUF3748 domain-containing protein	-
AM356_RS15810	3414395..3415279	+	885	WP_110706881.1	endonuclease/exonuclease/phosphatase family protein	-
AM356_RS15815	3415272..3415706	+	435	WP_004246827.1	hypothetical protein	-
AM356_RS15820	3415755..3416075	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
AM356_RS15825	3416068..3416454	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM356_RS15830	3416616..3418688	-	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
AM356_RS15835	3418698..3419603	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
AM356_RS15840	3419854..3420435	+	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T106541 WP_004249093.1 NZ_CP029725:c3416454-3416068 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T106541 NZ_CP029725:c3416454-3416068 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT106541 WP_004246828.1 NZ_CP029725:c3416075-3415755 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT106541 NZ_CP029725:c3416075-3415755 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGAATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97