Detailed information of TA system TA106539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 3092757..3093358
• Replicon: chromosome
• Accession: NZ_CP029725
• Organism: Proteus mirabilis strain AR_0029

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: AM356_RS14400
• Protein ID: WP_049194960.1
• Coordinates: 3092975..3093358 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: AM356_RS14395
• Protein ID: WP_004246496.1
• Coordinates: 3092757..3092978 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM356_RS14370	3088543..3089001	+	459	WP_004246490.1	dUTP diphosphatase	-
AM356_RS14375	3089121..3089726	+	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
AM356_RS14380	3090045..3090689	-	645	WP_004246493.1	orotate phosphoribosyltransferase	-
AM356_RS14385	3090770..3091486	-	717	WP_004249946.1	ribonuclease PH	-
AM356_RS14390	3091613..3092476	+	864	WP_004249947.1	YicC family protein	-
AM356_RS14395	3092757..3092978	+	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AM356_RS14400	3092975..3093358	+	384	WP_049194960.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
AM356_RS14405	3093765..3094079	+	315	WP_004246498.1	helix-turn-helix domain-containing protein	-
AM356_RS14410	3094379..3095278	-	900	WP_004246500.1	N-acetylmuramic acid 6-phosphate etherase	-
AM356_RS14415	3095554..3096117	-	564	WP_012368640.1	methyltransferase	-
AM356_RS14420	3096617..3097723	+	1107	WP_004249769.1	aspartate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-115)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14462.43 Da
• Isoelectric Point: 6.6451

>T106539 WP_049194960.1 NZ_CP029725:3092975-3093358 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T106539 NZ_CP029725:3092975-3093358 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACATTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATGATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATATGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT106539 WP_004246496.1 NZ_CP029725:3092757-3092978 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT106539 NZ_CP029725:3092757-3092978 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9