Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2254850..2255366 Replicon chromosome
Accession NZ_CP029722
Organism Klebsiella pneumoniae strain AR_0140

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag AM387_RS11335 Protein ID WP_009309309.1
Coordinates 2254850..2255134 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM387_RS11340 Protein ID WP_002886901.1
Coordinates 2255124..2255366 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM387_RS11315 2250334..2250642 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
AM387_RS29180 2250727..2250900 + 174 WP_032412860.1 hypothetical protein -
AM387_RS11320 2250903..2251646 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM387_RS11325 2252003..2254141 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AM387_RS11330 2254382..2254846 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM387_RS11335 2254850..2255134 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM387_RS11340 2255124..2255366 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM387_RS11345 2255444..2257354 - 1911 WP_023280782.1 BglG family transcription antiterminator -
AM387_RS11350 2257377..2258531 - 1155 WP_023280781.1 lactonase family protein -
AM387_RS11355 2258598..2259338 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T106523 WP_009309309.1 NZ_CP029722:c2255134-2254850 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T106523 NZ_CP029722:c2255134-2254850 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCTGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT106523 WP_002886901.1 NZ_CP029722:c2255366-2255124 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT106523 NZ_CP029722:c2255366-2255124 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References