Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 111513..112039 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP029719 | ||
| Organism | Enterobacter cloacae complex sp. strain AR_0154 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A7R6HXL1 |
| Locus tag | AM401_RS26770 | Protein ID | WP_015572079.1 |
| Coordinates | 111513..111800 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AM401_RS26775 | Protein ID | WP_000534858.1 |
| Coordinates | 111800..112039 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM401_RS26735 (AM401_26730) | 107050..107691 | + | 642 | WP_015572084.1 | Arc family DNA-binding protein | - |
| AM401_RS26740 (AM401_26735) | 107730..108116 | - | 387 | WP_015572083.1 | relaxosome protein TraM | - |
| AM401_RS26745 (AM401_26740) | 108715..109254 | + | 540 | WP_032664846.1 | lytic transglycosylase domain-containing protein | - |
| AM401_RS26750 (AM401_26745) | 109283..110104 | - | 822 | WP_015572081.1 | DUF932 domain-containing protein | - |
| AM401_RS26755 (AM401_26750) | 110121..110414 | - | 294 | WP_032670838.1 | hypothetical protein | - |
| AM401_RS26765 (AM401_26760) | 111287..111460 | - | 174 | WP_229231590.1 | DUF5431 family protein | - |
| AM401_RS26770 (AM401_26765) | 111513..111800 | - | 288 | WP_015572079.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AM401_RS26775 (AM401_26770) | 111800..112039 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AM401_RS28105 | 112064..112166 | + | 103 | Protein_121 | hypothetical protein | - |
| AM401_RS26780 (AM401_26775) | 112388..112708 | - | 321 | WP_004197483.1 | hypothetical protein | - |
| AM401_RS26785 (AM401_26780) | 113172..113987 | + | 816 | WP_032670836.1 | SDR family oxidoreductase | - |
| AM401_RS26790 (AM401_26785) | 114017..114778 | + | 762 | WP_004118132.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| AM401_RS26795 (AM401_26790) | 114821..116020 | + | 1200 | WP_032670835.1 | MFS transporter | - |
| AM401_RS26800 (AM401_26795) | 116031..116966 | + | 936 | WP_004118100.1 | GlxA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..138933 | 138933 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11209.09 Da Isoelectric Point: 10.0714
>T106518 WP_015572079.1 NZ_CP029719:c111800-111513 [Enterobacter cloacae complex sp.]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T106518 NZ_CP029719:c111800-111513 [Enterobacter cloacae complex sp.]
ATGGCATATTTTCTGGATTTTGACGAGCGTGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGCTAAA
AAATAAGTTGGCTGAAGTGCTTGAGTCACCCCGAATTGATGCGAACAAGCTTCGGGGTATGCATGACTGTTACAAAATTA
AGCTCCGGTCTTCAGGCTATCGTCTTGTATATCAGGTCATAGACGAGAAGGTTGTCGTCTTTGTGATTTCTGTCGGGAAA
AGAGAGCGCTCGGAAGTTTATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCATATTTTCTGGATTTTGACGAGCGTGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGCTAAA
AAATAAGTTGGCTGAAGTGCTTGAGTCACCCCGAATTGATGCGAACAAGCTTCGGGGTATGCATGACTGTTACAAAATTA
AGCTCCGGTCTTCAGGCTATCGTCTTGTATATCAGGTCATAGACGAGAAGGTTGTCGTCTTTGTGATTTCTGTCGGGAAA
AGAGAGCGCTCGGAAGTTTATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT106518 WP_000534858.1 NZ_CP029719:c112039-111800 [Enterobacter cloacae complex sp.]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT106518 NZ_CP029719:c112039-111800 [Enterobacter cloacae complex sp.]
ATGGGTAGCATCAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCTGCGCTTGAAAAAATGGGTGTAACTCC
CTCTGAGGCACTTCGCCTCATGCTTGAATATATTGCTGACAATGAACGTTTGCCGTTCAAACAGACACTCCTGAGTGATG
AGGATGCTGAGCTCGTGGAGATCGTGAAAGAACGACTTCGCAATCCTAAGCCAGTACGTGTGACGCTGGATGAGCTCTGA
ATGGGTAGCATCAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCTGCGCTTGAAAAAATGGGTGTAACTCC
CTCTGAGGCACTTCGCCTCATGCTTGAATATATTGCTGACAATGAACGTTTGCCGTTCAAACAGACACTCCTGAGTGATG
AGGATGCTGAGCTCGTGGAGATCGTGAAAGAACGACTTCGCAATCCTAAGCCAGTACGTGTGACGCTGGATGAGCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 4FXE | |
| PDB | 2KC8 | |
| PDB | 2K29 | |
| AlphaFold DB | A0A4V1CTS8 |