Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 43922..44661 Replicon plasmid unnamed1
Accession NZ_CP029719
Organism Enterobacter cloacae complex sp. strain AR_0154

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag AM401_RS26410 Protein ID WP_013087269.1
Coordinates 44176..44661 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag AM401_RS26405 Protein ID WP_007869691.1
Coordinates 43922..44188 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM401_RS26380 (AM401_26375) 39477..40247 + 771 WP_032670855.1 TraX family protein -
AM401_RS26385 (AM401_26380) 40262..40585 + 324 WP_015572034.1 hypothetical protein -
AM401_RS26390 (AM401_26385) 40563..41366 - 804 WP_032670854.1 DUF4225 domain-containing protein -
AM401_RS26395 (AM401_26390) 42256..43269 - 1014 WP_032670853.1 plasmid replication initiator RepA -
AM401_RS26405 (AM401_26400) 43922..44188 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
AM401_RS26410 (AM401_26405) 44176..44661 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
AM401_RS26415 (AM401_26410) 45190..45420 + 231 WP_047746533.1 hypothetical protein -
AM401_RS26420 (AM401_26415) 45491..46585 + 1095 WP_032670851.1 hypothetical protein -
AM401_RS26425 (AM401_26420) 46879..48219 - 1341 WP_049126869.1 hypothetical protein -
AM401_RS26430 (AM401_26425) 48445..49434 + 990 WP_110871687.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..138933 138933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T106517 WP_013087269.1 NZ_CP029719:44176-44661 [Enterobacter cloacae complex sp.]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T106517 NZ_CP029719:44176-44661 [Enterobacter cloacae complex sp.]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT106517 WP_007869691.1 NZ_CP029719:43922-44188 [Enterobacter cloacae complex sp.]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT106517 NZ_CP029719:43922-44188 [Enterobacter cloacae complex sp.]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References