Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4586382..4587039 Replicon chromosome
Accession NZ_CP029716
Organism Enterobacter cloacae complex sp. strain AR_0154

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag AM401_RS22685 Protein ID WP_023295382.1
Coordinates 4586629..4587039 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM401_RS22680 Protein ID WP_003863437.1
Coordinates 4586382..4586648 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM401_RS22660 (AM401_22655) 4581788..4583221 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
AM401_RS22665 (AM401_22660) 4583341..4584069 - 729 WP_039269836.1 MurR/RpiR family transcriptional regulator -
AM401_RS22670 (AM401_22665) 4584336..4584995 + 660 WP_003863433.1 hemolysin III family protein -
AM401_RS22675 (AM401_22670) 4585107..4586087 - 981 WP_039269839.1 tRNA-modifying protein YgfZ -
AM401_RS22680 (AM401_22675) 4586382..4586648 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM401_RS22685 (AM401_22680) 4586629..4587039 + 411 WP_023295382.1 protein YgfX Toxin
AM401_RS22690 (AM401_22685) 4587041..4587562 - 522 WP_015571793.1 flavodoxin FldB -
AM401_RS22695 (AM401_22690) 4587664..4588560 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AM401_RS22700 (AM401_22695) 4588589..4589302 + 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM401_RS22705 (AM401_22700) 4589308..4591041 + 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T106513 WP_023295382.1 NZ_CP029716:4586629-4587039 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T106513 NZ_CP029716:4586629-4587039 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT106513 WP_003863437.1 NZ_CP029716:4586382-4586648 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT106513 NZ_CP029716:4586382-4586648 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References