Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | KacT-ataR/DUF1778(antitoxin) |
| Location | 1927557..1928354 | Replicon | chromosome |
| Accession | NZ_CP029716 | ||
| Organism | Enterobacter cloacae complex sp. strain AR_0154 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | AM401_RS09650 | Protein ID | WP_110870847.1 |
| Coordinates | 1927557..1928078 (-) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A331QJY7 |
| Locus tag | AM401_RS09655 | Protein ID | WP_015570876.1 |
| Coordinates | 1928085..1928354 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM401_RS09620 (AM401_09620) | 1923155..1923844 | + | 690 | WP_045349209.1 | pyrimidine utilization protein B | - |
| AM401_RS09625 (AM401_09625) | 1923856..1924242 | + | 387 | WP_015570870.1 | pyrimidine utilization protein C | - |
| AM401_RS09630 (AM401_09630) | 1924250..1925050 | + | 801 | WP_110870841.1 | pyrimidine utilization protein D | - |
| AM401_RS09635 (AM401_09635) | 1925060..1925650 | + | 591 | WP_110870843.1 | malonic semialdehyde reductase | - |
| AM401_RS09640 (AM401_09640) | 1925663..1926154 | + | 492 | WP_110870845.1 | pyrimidine utilization flavin reductase protein F | - |
| AM401_RS09645 (AM401_09645) | 1926176..1927498 | + | 1323 | WP_047717623.1 | pyrimidine utilization transport protein G | - |
| AM401_RS09650 (AM401_09650) | 1927557..1928078 | - | 522 | WP_110870847.1 | GNAT family N-acetyltransferase | Toxin |
| AM401_RS09655 (AM401_09655) | 1928085..1928354 | - | 270 | WP_015570876.1 | DUF1778 domain-containing protein | Antitoxin |
| AM401_RS09660 (AM401_09660) | 1928428..1929333 | - | 906 | WP_032653183.1 | DMT family transporter | - |
| AM401_RS09665 (AM401_09665) | 1929450..1929620 | - | 171 | WP_001273664.1 | general stress protein | - |
| AM401_RS09670 (AM401_09670) | 1930012..1930608 | + | 597 | WP_006809323.1 | NAD(P)H:quinone oxidoreductase | - |
| AM401_RS09675 (AM401_09675) | 1930627..1930854 | + | 228 | WP_006809324.1 | YccJ family protein | - |
| AM401_RS09680 (AM401_09680) | 1930887..1932128 | - | 1242 | WP_047729185.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
| AM401_RS27970 | 1932281..1932376 | + | 96 | Protein_1867 | transcriptional regulator | - |
| AM401_RS09690 (AM401_09690) | 1932455..1932814 | - | 360 | WP_017384779.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19463.27 Da Isoelectric Point: 7.4318
>T106509 WP_110870847.1 NZ_CP029716:c1928078-1927557 [Enterobacter cloacae complex sp.]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKIQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKIQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
Download Length: 522 bp
>T106509 NZ_CP029716:c1928078-1927557 [Enterobacter cloacae complex sp.]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGATTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGATTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10247.75 Da Isoelectric Point: 5.8836
>AT106509 WP_015570876.1 NZ_CP029716:c1928354-1928085 [Enterobacter cloacae complex sp.]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT106509 NZ_CP029716:c1928354-1928085 [Enterobacter cloacae complex sp.]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|