Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1761036..1761647 | Replicon | chromosome |
| Accession | NZ_CP029716 | ||
| Organism | Enterobacter cloacae complex sp. strain AR_0154 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | D2TUP9 |
| Locus tag | AM401_RS08700 | Protein ID | WP_012906750.1 |
| Coordinates | 1761036..1761215 (+) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A6G3F240 |
| Locus tag | AM401_RS08705 | Protein ID | WP_045339414.1 |
| Coordinates | 1761237..1761647 (+) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM401_RS08655 (AM401_08655) | 1756071..1756325 | - | 255 | WP_045341642.1 | DUF333 domain-containing protein | - |
| AM401_RS08660 (AM401_08660) | 1756637..1757665 | + | 1029 | WP_045344202.1 | sensor domain-containing diguanylate cyclase | - |
| AM401_RS08665 (AM401_08665) | 1757711..1757809 | + | 99 | WP_015570793.1 | YoaK family small membrane protein | - |
| AM401_RS08675 (AM401_08675) | 1757938..1758186 | - | 249 | WP_003857896.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| AM401_RS08680 (AM401_08680) | 1758556..1758648 | + | 93 | WP_071524166.1 | stress response membrane protein YncL | - |
| AM401_RS08685 (AM401_08685) | 1758773..1760272 | + | 1500 | WP_110870786.1 | cyclic diguanylate phosphodiesterase | - |
| AM401_RS08690 (AM401_08690) | 1760277..1760522 | - | 246 | WP_022650806.1 | YmjA family protein | - |
| AM401_RS08695 (AM401_08695) | 1760598..1760768 | - | 171 | Protein_1678 | isocitrate/isopropylmalate family dehydrogenase | - |
| AM401_RS08700 (AM401_08700) | 1761036..1761215 | + | 180 | WP_012906750.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| AM401_RS08705 (AM401_08705) | 1761237..1761647 | + | 411 | WP_045339414.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| AM401_RS08710 (AM401_08710) | 1761729..1762295 | + | 567 | WP_047353913.1 | serine acetyltransferase | - |
| AM401_RS08715 (AM401_08715) | 1762299..1762721 | - | 423 | WP_064489211.1 | tail fiber assembly protein | - |
| AM401_RS27950 | 1762723..1765284 | - | 2562 | WP_160160621.1 | phage tail protein | - |
| AM401_RS08725 (AM401_08725) | 1765287..1765838 | - | 552 | WP_045345258.1 | phage tail protein I | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1761036..1804704 | 43668 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6644.85 Da Isoelectric Point: 10.9132
>T106508 WP_012906750.1 NZ_CP029716:1761036-1761215 [Enterobacter cloacae complex sp.]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
Download Length: 180 bp
>T106508 NZ_CP029716:1761036-1761215 [Enterobacter cloacae complex sp.]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTGAAAGGCAGCCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTGAAAGGCAGCCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14890.79 Da Isoelectric Point: 4.3170
>AT106508 WP_045339414.1 NZ_CP029716:1761237-1761647 [Enterobacter cloacae complex sp.]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
Download Length: 411 bp
>AT106508 NZ_CP029716:1761237-1761647 [Enterobacter cloacae complex sp.]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATTGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCAGAAGCAACGACCGTCGAAAACTGGCTTTCTGATCCGGAGTATGCCGGTGCTGTATGGGCCCTGGTTGAC
GTGGATATAACTCGTCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCTTCACTGCTGATCCGACGTATCGATCA
GTTTGTGGCCGCGCATCCTGAATATGGCAGCCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATTGGACGAG
AAAAACGATAA
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATTGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCAGAAGCAACGACCGTCGAAAACTGGCTTTCTGATCCGGAGTATGCCGGTGCTGTATGGGCCCTGGTTGAC
GTGGATATAACTCGTCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCTTCACTGCTGATCCGACGTATCGATCA
GTTTGTGGCCGCGCATCCTGAATATGGCAGCCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATTGGACGAG
AAAAACGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D6XDK4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6G3F240 |