Detailed information of TA system TA106507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1267590..1268329
• Replicon: chromosome
• Accession: NZ_CP029716
• Organism: Enterobacter cloacae complex sp. strain AR_0154

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A801DRD7
• Locus tag: AM401_RS06160
• Protein ID: WP_017693417.1
• Coordinates: 1267844..1268329 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: AM401_RS06155
• Protein ID: WP_003857131.1
• Coordinates: 1267590..1267856 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM401_RS06135 (AM401_06135)	1263072..1264058	+	987	WP_023296632.1	DUF979 domain-containing protein	-
AM401_RS06140 (AM401_06140)	1264068..1265063	+	996	WP_015570513.1	DUF2891 domain-containing protein	-
AM401_RS06145 (AM401_06145)	1265085..1266467	-	1383	WP_110870590.1	MFS transporter	-
AM401_RS06150 (AM401_06150)	1266597..1267526	+	930	WP_110870592.1	LysR family transcriptional regulator	-
AM401_RS06155 (AM401_06155)	1267590..1267856	+	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
AM401_RS06160 (AM401_06160)	1267844..1268329	+	486	WP_017693417.1	GNAT family N-acetyltransferase	Toxin
AM401_RS06165 (AM401_06165)	1268507..1269799	-	1293	WP_110870594.1	glycosyl hydrolase family 28 protein	-
AM401_RS06170 (AM401_06170)	1269904..1270662	-	759	WP_047637345.1	DeoR/GlpR family DNA-binding transcription regulator	-
AM401_RS06175 (AM401_06175)	1270749..1271333	+	585	WP_017382349.1	GDP-mannose pyrophosphatase nudK	-
AM401_RS06180 (AM401_06180)	1271418..1272176	+	759	WP_063151482.1	trans-aconitate 2-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (58-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17570.26 Da
• Isoelectric Point: 9.9658

>T106507 WP_017693417.1 NZ_CP029716:1267844-1268329 [Enterobacter cloacae complex sp.]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKTFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T106507 NZ_CP029716:1267844-1268329 [Enterobacter cloacae complex sp.]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAACGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT106507 WP_003857131.1 NZ_CP029716:1267590-1267856 [Enterobacter cloacae complex sp.]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT106507 NZ_CP029716:1267590-1267856 [Enterobacter cloacae complex sp.]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9