Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4269047..4269519 Replicon chromosome
Accession NZ_CP029715
Organism Serratia marcescens strain AR_0131

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AM378_RS20265 Protein ID WP_033649650.1
Coordinates 4269244..4269519 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AM378_RS20260 Protein ID WP_033649649.1
Coordinates 4269047..4269244 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM378_RS20230 4264240..4265508 + 1269 WP_043148323.1 glycerol-3-phosphate dehydrogenase subunit GlpB -
AM378_RS20235 4265505..4266704 + 1200 WP_033636667.1 anaerobic glycerol-3-phosphate dehydrogenase subunit C -
AM378_RS20240 4266740..4267303 - 564 WP_033636670.1 DcrB family lipoprotein -
AM378_RS20245 4267384..4267818 - 435 WP_033649647.1 GNAT family N-acetyltransferase -
AM378_RS20250 4267860..4268519 - 660 WP_033649648.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
AM378_RS20255 4268740..4268985 + 246 WP_025304890.1 sulfurtransferase TusA -
AM378_RS20260 4269047..4269244 + 198 WP_033649649.1 hypothetical protein Antitoxin
AM378_RS20265 4269244..4269519 + 276 WP_033649650.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AM378_RS20270 4269579..4271897 - 2319 WP_048321227.1 zinc/cadmium/mercury/lead-transporting ATPase -
AM378_RS20275 4272579..4274042 + 1464 WP_033636674.1 serralysin family metalloprotease -
AM378_RS20280 4274098..4274475 + 378 WP_033649652.1 AprI/Inh family metalloprotease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10638.51 Da        Isoelectric Point: 11.2806

>T106499 WP_033649650.1 NZ_CP029715:4269244-4269519 [Serratia marcescens]
MLNIEWTRAARQDLAEIVGFIANDNPLAARKMKVLIMEAVIPAGRHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRA
LRVLHTRRQYP

Download         Length: 276 bp

>T106499 NZ_CP029715:4269244-4269519 [Serratia marcescens]
ATGCTCAACATCGAATGGACTCGAGCCGCACGTCAGGATCTGGCGGAGATTGTGGGATTCATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGTTCTCATCATGGAGGCCGTCATTCCCGCCGGCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTACATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGCG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7398.49 Da        Isoelectric Point: 4.4143

>AT106499 WP_033649649.1 NZ_CP029715:4269047-4269244 [Serratia marcescens]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Download         Length: 198 bp

>AT106499 NZ_CP029715:4269047-4269244 [Serratia marcescens]
ATGAGTATTTTACTACTGCCTACGGTTGCCAAGATGGAAAATGAGGAACGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCGCGGCCCGGCATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References