Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3246826..3247472 Replicon chromosome
Accession NZ_CP029710
Organism Nocardia sp. CS682

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DMB37_RS14630 Protein ID WP_135233176.1
Coordinates 3247080..3247472 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DMB37_RS14625 Protein ID WP_167768843.1
Coordinates 3246826..3247083 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB37_RS14600 3242186..3242968 + 783 WP_135233172.1 hypothetical protein -
DMB37_RS14605 3243171..3243530 + 360 WP_135233173.1 hypothetical protein -
DMB37_RS14610 3243583..3244293 - 711 WP_135233174.1 DUF1906 domain-containing protein -
DMB37_RS14615 3244657..3245778 - 1122 Protein_2922 hypothetical protein -
DMB37_RS14620 3246011..3246664 - 654 WP_135233175.1 CHAP domain-containing protein -
DMB37_RS14625 3246826..3247083 + 258 WP_167768843.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DMB37_RS14630 3247080..3247472 + 393 WP_135233176.1 type II toxin-antitoxin system VapC family toxin Toxin
DMB37_RS14635 3247578..3248228 + 651 WP_135233177.1 ABC transporter permease -
DMB37_RS14640 3248221..3249420 + 1200 WP_135233178.1 ATP-binding cassette domain-containing protein -
DMB37_RS14645 3249417..3250199 + 783 WP_135233179.1 ABC transporter permease subunit -
DMB37_RS14650 3250196..3251170 + 975 WP_135233180.1 glycine betaine ABC transporter substrate-binding protein -
DMB37_RS14655 3251305..3251952 - 648 WP_135233181.1 TIGR03086 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(2-84)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14059.95 Da        Isoelectric Point: 5.1687

>T106480 WP_135233176.1 NZ_CP029710:3247080-3247472 [Nocardia sp. CS682]
MIVDASALLAIINQEPERGSFIDALDSAESRSMSVVNHFEVAIKVDRSPDPIIARRFAELINDGDIELAPVSLEQAAIAR
AAYRDFGKGSGHKAQLNLGDCFAYALATVTKKPLLYKGNDFGHTDIRSAV

Download         Length: 393 bp

>T106480 NZ_CP029710:3247080-3247472 [Nocardia sp. CS682]
ATGATCGTCGACGCATCGGCTCTGCTCGCCATCATCAACCAGGAACCCGAACGAGGCAGCTTCATCGATGCACTCGATTC
GGCGGAGAGCCGGTCGATGTCGGTGGTCAACCACTTCGAAGTGGCGATCAAAGTAGATCGCAGTCCGGACCCGATCATCG
CGCGCCGGTTCGCGGAGTTGATCAACGACGGCGACATCGAGCTCGCTCCCGTCTCGCTGGAGCAGGCCGCTATCGCACGT
GCTGCGTATCGCGATTTCGGCAAGGGCAGCGGACACAAGGCACAACTCAACCTCGGCGACTGCTTCGCCTACGCACTCGC
CACCGTCACCAAGAAGCCGCTGCTGTACAAGGGCAACGACTTCGGCCACACCGATATCCGATCCGCGGTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9712.03 Da        Isoelectric Point: 4.9060

>AT106480 WP_167768843.1 NZ_CP029710:3246826-3247083 [Nocardia sp. CS682]
MNIKNEKVHALVREAAERTGMSQTSVVEEALKRMLKELDAEREAARQTRKARLWEIVADIDARMTPETRTLLTTDDLYDD
QGLPA

Download         Length: 258 bp

>AT106480 NZ_CP029710:3246826-3247083 [Nocardia sp. CS682]
TTGAACATAAAAAATGAGAAGGTGCACGCCTTGGTGCGTGAGGCAGCGGAGCGGACGGGGATGTCCCAAACCAGCGTTGT
CGAGGAGGCACTGAAACGCATGTTGAAGGAACTGGATGCCGAGCGCGAAGCGGCACGACAGACCCGAAAGGCTCGGCTCT
GGGAGATCGTGGCGGATATCGACGCCAGGATGACACCGGAGACCCGCACCTTGCTGACCACCGATGATCTCTACGACGAT
CAGGGGCTGCCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References