Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 2053424..2054148 Replicon chromosome
Accession NZ_CP029710
Organism Nocardia sp. CS682

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DMB37_RS09085 Protein ID WP_135237446.1
Coordinates 2053424..2053846 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DMB37_RS09090 Protein ID WP_135232318.1
Coordinates 2053867..2054148 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB37_RS09060 2049486..2050172 - 687 WP_107658256.1 response regulator transcription factor -
DMB37_RS09065 2050338..2050793 - 456 WP_167768785.1 flavodoxin family protein -
DMB37_RS09070 2051173..2051682 - 510 WP_135232315.1 hypothetical protein -
DMB37_RS09075 2051720..2052466 - 747 WP_135232316.1 4-hydroxy-tetrahydrodipicolinate reductase -
DMB37_RS09080 2052602..2053423 + 822 WP_167768786.1 alpha/beta hydrolase -
DMB37_RS09085 2053424..2053846 - 423 WP_135237446.1 type II toxin-antitoxin system VapC family toxin Toxin
DMB37_RS09090 2053867..2054148 - 282 WP_135232318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DMB37_RS09095 2054322..2055434 - 1113 WP_135232319.1 alcohol dehydrogenase catalytic domain-containing protein -
DMB37_RS09100 2055480..2056682 - 1203 WP_135232320.1 DUF418 domain-containing protein -
DMB37_RS09105 2056880..2057527 + 648 WP_206055219.1 response regulator -
DMB37_RS09110 2057524..2058606 + 1083 WP_135232322.1 two-component sensor histidine kinase -
DMB37_RS09115 2058748..2059143 + 396 WP_135237447.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-128)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-71)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15802.01 Da        Isoelectric Point: 7.2818

>T106479 WP_135237446.1 NZ_CP029710:c2053846-2053424 [Nocardia sp. CS682]
MGYLLDTNAVSEWIKPRPDPGLIEWLHDADEERMFLSVITIGEIRRGVDRMSNGRRKARLTTWLSDQVTDRFDARLLPID
LGVAQAWGRIRARAERAGHRVDAVDALIAATAEAHGLAVVTRNEKDFRGTGVQVLCPWRE

Download         Length: 423 bp

>T106479 NZ_CP029710:c2053846-2053424 [Nocardia sp. CS682]
ATGGGCTACCTCCTGGACACGAACGCCGTCTCGGAATGGATCAAGCCCCGCCCGGACCCCGGACTGATCGAATGGCTGCA
CGACGCCGACGAGGAACGAATGTTCCTGAGCGTCATCACGATCGGGGAGATCCGCCGCGGCGTCGATCGGATGTCCAACG
GGCGGCGCAAGGCGCGCTTGACCACGTGGCTGTCCGACCAGGTCACCGACCGATTCGACGCGCGACTACTGCCGATCGAC
CTCGGTGTCGCGCAGGCGTGGGGTCGCATCCGCGCCAGAGCCGAAAGAGCCGGGCATCGGGTCGACGCCGTGGACGCGCT
CATTGCGGCAACCGCGGAAGCACACGGACTCGCCGTCGTCACTCGCAACGAGAAGGACTTCCGTGGCACGGGAGTGCAGG
TGTTGTGTCCATGGCGGGAATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10682.05 Da        Isoelectric Point: 7.2077

>AT106479 WP_135232318.1 NZ_CP029710:c2054148-2053867 [Nocardia sp. CS682]
MARKRSERPDVAWPLADAKARLSELIDTVEREGPQVISKHGREVAVVVPIDEWRRRNARQGSLAEFFADSPLRDPELVVT
RDRTDPQHRDVTL

Download         Length: 282 bp

>AT106479 NZ_CP029710:c2054148-2053867 [Nocardia sp. CS682]
ATGGCACGAAAGCGGTCGGAGCGACCAGATGTCGCATGGCCTCTCGCCGACGCGAAGGCCAGGTTGTCCGAGTTGATCGA
CACGGTGGAACGGGAGGGACCGCAGGTGATCAGCAAGCATGGACGTGAAGTGGCCGTTGTCGTACCGATCGACGAATGGC
GGCGCCGGAATGCGCGACAGGGCAGTCTGGCCGAGTTCTTCGCCGACTCCCCCCTACGCGACCCGGAGCTGGTCGTGACC
CGGGACAGGACGGATCCGCAGCACCGCGACGTGACCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References