Detailed information of TA system TA106473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1078828..1079344
• Replicon: chromosome
• Accession: NZ_CP029707
• Organism: Pseudomonas aeruginosa strain K34-7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DCS61_RS05330
• Protein ID: WP_071557699.1
• Coordinates: 1079063..1079344 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A482UCX2
• Locus tag: DCS61_RS05325
• Protein ID: WP_033942931.1
• Coordinates: 1078828..1079073 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCS61_RS05315	1074554..1077721	+	3168	WP_033942936.1	DEAD/DEAH box helicase	-
DCS61_RS05320	1077845..1078303	+	459	Protein_1022	hypothetical protein	-
DCS61_RS33940	1078221..1078658	-	438	WP_033942934.1	hypothetical protein	-
DCS61_RS05325	1078828..1079073	+	246	WP_033942931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DCS61_RS05330	1079063..1079344	+	282	WP_071557699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DCS61_RS05335	1079598..1080095	-	498	WP_033942928.1	DNA repair protein RadC	-
DCS61_RS05340	1080106..1081017	-	912	WP_033942927.1	hypothetical protein	-
DCS61_RS05345	1081110..1082114	-	1005	WP_033942926.1	YqaJ viral recombinase family protein	-
DCS61_RS05350	1082189..1083157	-	969	WP_033942925.1	DUF932 domain-containing protein	-
DCS61_RS05360	1083963..1084181	+	219	WP_071557701.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1058201..1099828	41627

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10721.55 Da
• Isoelectric Point: 10.6485

>T106473 WP_071557699.1 NZ_CP029707:1079063-1079344 [Pseudomonas aeruginosa]
MTYKLEFLPSALKEWEKLGHTVREQAKKKLRERLEAPKVQADALRDLPGHYKIKLRTAGYRLVYNVEDDRVVVIVVAVGK
RERSAAYKAAGKR

Nucleotide

• Length: 282 bp

>T106473 NZ_CP029707:1079063-1079344 [Pseudomonas aeruginosa]
ATGACCTATAAGCTCGAGTTCCTGCCCTCAGCGCTGAAGGAATGGGAGAAGCTGGGTCATACGGTGCGTGAGCAGGCAAA
GAAAAAACTGCGTGAGCGGCTGGAAGCACCAAAGGTACAGGCTGATGCCCTCAGGGATCTGCCTGGCCACTACAAGATCA
AGCTCCGAACAGCAGGCTATCGATTGGTCTATAATGTCGAGGATGATCGGGTGGTTGTGATTGTGGTCGCAGTGGGCAAG
CGTGAACGAAGTGCAGCTTACAAGGCAGCAGGTAAGCGTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8653.98 Da
• Isoelectric Point: 4.1469

>AT106473 WP_033942931.1 NZ_CP029707:1078828-1079073 [Pseudomonas aeruginosa]
MQSVLADVAVSVSELKKNPTGVMAGAGGMPVAVLNHNRVMGYMVPAELYEQMLDRLDDLDLIDVVNARSGEKGVPVNLDD
L

Nucleotide

• Length: 246 bp

>AT106473 NZ_CP029707:1078828-1079073 [Pseudomonas aeruginosa]
ATGCAGAGTGTTTTGGCTGACGTTGCCGTGAGCGTTTCTGAGCTGAAGAAAAACCCCACCGGTGTCATGGCTGGTGCGGG
TGGCATGCCGGTCGCAGTTCTCAATCATAACCGCGTGATGGGGTACATGGTGCCAGCCGAGCTGTACGAGCAGATGTTGG
ACCGTTTGGACGATCTGGATCTGATCGATGTCGTTAACGCGCGCTCCGGTGAGAAGGGTGTGCCGGTGAACCTGGATGAC
CTATAA

Structures

Antitoxin

• AlphaFold DB: A0A482UCX2