Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1639746..1640358 Replicon chromosome
Accession NZ_CP029694
Organism Streptococcus pyogenes strain ABC020055975

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DMC40_RS08665 Protein ID WP_002982731.1
Coordinates 1640023..1640358 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5S4TJ53
Locus tag DMC40_RS08660 Protein ID WP_011055007.1
Coordinates 1639746..1640033 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMC40_RS08635 1634938..1635921 - 984 WP_011055003.1 tagatose-bisphosphate aldolase -
DMC40_RS08640 1635925..1636854 - 930 WP_011055004.1 tagatose-6-phosphate kinase -
DMC40_RS08645 1636900..1637415 - 516 WP_011055005.1 galactose-6-phosphate isomerase subunit LacB -
DMC40_RS08650 1637450..1637878 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DMC40_RS08655 1638323..1639096 + 774 WP_011055006.1 DeoR/GlpR family DNA-binding transcription regulator -
DMC40_RS08660 1639746..1640033 + 288 WP_011055007.1 hypothetical protein Antitoxin
DMC40_RS08665 1640023..1640358 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DMC40_RS09925 1640425..1641496 + 1072 Protein_1610 site-specific integrase -
DMC40_RS08690 1641628..1642020 - 393 WP_002982716.1 30S ribosomal protein S9 -
DMC40_RS08695 1642041..1642487 - 447 WP_002982710.1 50S ribosomal protein L13 -
DMC40_RS08700 1642705..1642911 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DMC40_RS08705 1642908..1643606 - 699 WP_011055008.1 hypothetical protein -
DMC40_RS08710 1643733..1644593 - 861 WP_011055009.1 DegV family protein -
DMC40_RS08715 1644690..1645208 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T106470 WP_002982731.1 NZ_CP029694:1640023-1640358 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T106470 NZ_CP029694:1640023-1640358 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 5.2318

>AT106470 WP_011055007.1 NZ_CP029694:1639746-1640033 [Streptococcus pyogenes]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT106470 NZ_CP029694:1639746-1640033 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4TJ53

References