Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4522205..4522842 Replicon chromosome
Accession NZ_CP029693
Organism Pseudomonas putida strain JBC17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DKY63_RS21225 Protein ID WP_110965877.1
Coordinates 4522205..4522612 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DKY63_RS21230 Protein ID WP_110965878.1
Coordinates 4522612..4522842 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKY63_RS21205 4517851..4518546 - 696 WP_110965873.1 ABC transporter permease -
DKY63_RS21210 4518625..4519371 - 747 WP_110965874.1 ABC transporter substrate-binding protein -
DKY63_RS21215 4519385..4520158 - 774 WP_110965875.1 ABC transporter ATP-binding protein -
DKY63_RS21220 4520723..4522114 + 1392 WP_110965876.1 GABA permease -
DKY63_RS21225 4522205..4522612 - 408 WP_110965877.1 tRNA(fMet)-specific endonuclease VapC Toxin
DKY63_RS21230 4522612..4522842 - 231 WP_110965878.1 antitoxin Antitoxin
DKY63_RS21235 4523011..4523460 - 450 WP_110965879.1 hypothetical protein -
DKY63_RS21240 4523467..4523883 - 417 WP_110965880.1 hypothetical protein -
DKY63_RS21245 4523920..4524894 - 975 WP_110965881.1 alpha/beta fold hydrolase -
DKY63_RS21250 4524966..4526018 - 1053 WP_110965882.1 DUF1016 family protein -
DKY63_RS21255 4526280..4526729 + 450 WP_110965883.1 carboxypeptidase regulatory-like domain-containing protein -
DKY63_RS21265 4527000..4527272 - 273 WP_110965884.1 oxidative damage protection protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4498562..4526729 28167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15092.43 Da        Isoelectric Point: 7.2427

>T106467 WP_110965877.1 NZ_CP029693:c4522612-4522205 [Pseudomonas putida]
MIKYMLDTNICIFTIKNKPQVVRDAFNRHYGQLCISAVTLMELVYGAEKSAAPEKNLSIVEGFAARLEILPFDNEAAAHT
GMIRSELARSGKPIGPYDYLIAGHARSRGLIVVTNNVREFERVPGIRVEDWVDTP

Download         Length: 408 bp

>T106467 NZ_CP029693:c4522612-4522205 [Pseudomonas putida]
ATGATCAAATACATGCTGGATACCAACATCTGCATCTTTACCATCAAGAACAAACCACAGGTCGTGCGCGACGCGTTCAA
CCGTCATTACGGCCAGCTGTGCATCAGTGCCGTAACCCTGATGGAGCTGGTCTACGGGGCGGAAAAATCCGCAGCCCCCG
AAAAGAACCTGTCTATCGTCGAGGGATTCGCAGCCCGCCTTGAGATCTTGCCTTTCGACAATGAAGCAGCTGCACACACC
GGAATGATTCGGTCCGAACTGGCAAGAAGCGGAAAGCCAATTGGTCCTTACGACTACCTGATCGCGGGCCATGCGCGCTC
ACGAGGACTCATCGTAGTCACGAACAACGTGCGGGAGTTTGAACGGGTACCGGGAATTCGCGTAGAAGACTGGGTCGACA
CACCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8532.52 Da        Isoelectric Point: 4.3569

>AT106467 WP_110965878.1 NZ_CP029693:c4522842-4522612 [Pseudomonas putida]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVDVVAVGRARIITPAGEAWDSWFDGDNVSADFMTDREQPADQERESF

Download         Length: 231 bp

>AT106467 NZ_CP029693:c4522842-4522612 [Pseudomonas putida]
ATGGAACAAACCACCCTATTCATGAGCAATCGAAGCCAAGCGGTTCGCCTACCCAAGGCTGTTGCAATGCCTAGCGATGT
TAAACGAGTGGATGTGGTCGCCGTAGGTAGAGCTCGTATCATCACGCCTGCCGGTGAAGCATGGGATAGCTGGTTCGACG
GCGACAATGTCTCTGCGGACTTCATGACCGATCGCGAGCAACCCGCTGATCAGGAGCGTGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References