Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2079004..2079642 Replicon chromosome
Accession NZ_CP029692
Organism Escherichia coli strain SD134209

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag DL800_RS12790 Protein ID WP_000813794.1
Coordinates 2079466..2079642 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DL800_RS12785 Protein ID WP_001270286.1
Coordinates 2079004..2079420 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DL800_RS12765 2074156..2075097 - 942 WP_001251315.1 ABC transporter permease -
DL800_RS12770 2075098..2076111 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
DL800_RS12775 2076129..2077274 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
DL800_RS12780 2077519..2078925 - 1407 WP_000760637.1 PLP-dependent aminotransferase family protein -
DL800_RS12785 2079004..2079420 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
DL800_RS12790 2079466..2079642 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
DL800_RS12795 2079864..2080094 + 231 WP_000494244.1 YncJ family protein -
DL800_RS12800 2080186..2082147 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
DL800_RS12805 2082220..2082756 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
DL800_RS12810 2082809..2084017 + 1209 WP_071532666.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2084057..2085205 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T106452 WP_000813794.1 NZ_CP029692:c2079642-2079466 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T106452 NZ_CP029692:c2079642-2079466 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT106452 WP_001270286.1 NZ_CP029692:c2079420-2079004 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT106452 NZ_CP029692:c2079420-2079004 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References