Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1005673..1006178 Replicon chromosome
Accession NZ_CP029685
Organism Staphylococcus aureus strain CMRSA-3

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag C7M54_RS05330 Protein ID WP_001103946.1
Coordinates 1005885..1006178 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag C7M54_RS05325 Protein ID WP_001058492.1
Coordinates 1005673..1005882 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M54_RS05290 1001190..1002410 - 1221 WP_000264182.1 site-specific integrase -
C7M54_RS05295 1002498..1003226 - 729 WP_000733773.1 staphylococcal enterotoxin type K -
C7M54_RS05300 1003250..1003978 - 729 WP_001033317.1 staphylococcal enterotoxin type Q -
C7M54_RS05305 1004153..1004887 - 735 WP_000142630.1 helix-turn-helix domain-containing protein -
C7M54_RS05310 1005037..1005249 + 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
C7M54_RS05315 1005250..1005522 + 273 WP_001138298.1 helix-turn-helix domain-containing protein -
C7M54_RS05320 1005534..1005680 + 147 WP_000784885.1 hypothetical protein -
C7M54_RS05325 1005673..1005882 + 210 WP_001058492.1 hypothetical protein Antitoxin
C7M54_RS05330 1005885..1006178 + 294 WP_001103946.1 DUF1474 family protein Toxin
C7M54_RS05335 1006266..1007135 + 870 WP_001002691.1 primase alpha helix C-terminal domain-containing protein -
C7M54_RS05340 1007152..1008609 + 1458 WP_000432707.1 virulence-associated E family protein -
C7M54_RS05345 1008911..1009273 + 363 WP_001039172.1 hypothetical protein -
C7M54_RS05350 1009275..1009559 + 285 WP_000998180.1 hypothetical protein -
C7M54_RS05355 1009556..1010197 + 642 WP_001019783.1 hypothetical protein -
C7M54_RS05360 1010646..1010987 + 342 WP_001190616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ant(9)-Ia / erm(A) selk / selq 976552..1013301 36749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T106375 WP_001103946.1 NZ_CP029685:1005885-1006178 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

>T106375 NZ_CP029685:1005885-1006178 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT106375 WP_001058492.1 NZ_CP029685:1005673-1005882 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT106375 NZ_CP029685:1005673-1005882 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References