Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 981869..982346 Replicon chromosome
Accession NZ_CP029685
Organism Staphylococcus aureus strain CMRSA-3

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag C7M54_RS05145 Protein ID WP_000052078.1
Coordinates 981869..982057 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C7M54_RS05150 Protein ID WP_001059690.1
Coordinates 982086..982346 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M54_RS05115 977909..978379 + 471 WP_000824472.1 hypothetical protein -
C7M54_RS05120 978720..979406 + 687 WP_001548082.1 thermonuclease family protein -
C7M54_RS05125 979763..979963 + 201 WP_001059082.1 cold-shock protein -
C7M54_RS05130 980460..980678 - 219 WP_000005886.1 hypothetical protein -
C7M54_RS05135 980740..981024 - 285 WP_001004395.1 hypothetical protein -
C7M54_RS05140 981112..981681 - 570 WP_001106654.1 hypothetical protein -
C7M54_RS05145 981869..982057 - 189 WP_000052078.1 hypothetical protein Toxin
C7M54_RS05150 982086..982346 - 261 WP_001059690.1 hypothetical protein Antitoxin
C7M54_RS05155 982687..982890 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C7M54_RS05160 982887..983123 - 237 WP_000368687.1 hypothetical protein -
C7M54_RS05165 983348..983929 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
C7M54_RS05170 984002..984619 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
C7M54_RS05175 984774..985268 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
C7M54_RS05180 985667..986089 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
C7M54_RS05185 986237..986953 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ant(9)-Ia / erm(A) selk / selq 976552..1013301 36749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T106374 WP_000052078.1 NZ_CP029685:c982057-981869 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106374 NZ_CP029685:c982057-981869 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106374 WP_001059690.1 NZ_CP029685:c982346-982086 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106374 NZ_CP029685:c982346-982086 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References