Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 55531..56053 Replicon plasmid pFORC89
Accession NZ_CP029683
Organism Salmonella sp. FORC89

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag FORC89_RS23075 Protein ID WP_000220561.1
Coordinates 55772..56053 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag FORC89_RS23070 Protein ID WP_000121743.1
Coordinates 55531..55782 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC89_RS23050 (FORC89_p079) 51801..52154 - 354 WP_024156393.1 DNA distortion polypeptide 3 -
FORC89_RS23055 (FORC89_p080) 52291..52737 - 447 WP_001074378.1 hypothetical protein -
FORC89_RS23060 (FORC89_p081) 52741..53592 - 852 WP_000435059.1 replication initiation protein -
FORC89_RS23065 (FORC89_p082) 53597..54466 - 870 WP_001212191.1 replication initiation protein -
FORC89_RS23070 (FORC89_p084) 55531..55782 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
FORC89_RS23075 (FORC89_p085) 55772..56053 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC89_RS23080 (FORC89_p086) 56403..56918 + 516 WP_001025387.1 J domain-containing protein -
FORC89_RS23085 (FORC89_p087) 56992..57540 + 549 WP_001178641.1 hypothetical protein -
FORC89_RS23090 (FORC89_p088) 57549..57818 + 270 WP_001006718.1 hypothetical protein -
FORC89_RS23095 (FORC89_p089) 57808..58050 + 243 WP_000008708.1 hypothetical protein -
FORC89_RS23100 (FORC89_p090) 58144..58473 + 330 WP_000866654.1 hypothetical protein -
FORC89_RS23105 (FORC89_p091) 58516..58695 + 180 WP_000439079.1 hypothetical protein -
FORC89_RS23110 58928..59200 + 273 WP_000167280.1 hypothetical protein -
FORC89_RS23115 (FORC89_p094) 59526..60071 + 546 WP_000757692.1 DNA distortion polypeptide 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catA2 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B fdeC / spvC / spvB / rck / pefD / pefC / pefA / pefB 1..86805 86805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T106373 WP_000220561.1 NZ_CP029683:55772-56053 [Salmonella sp. FORC89]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T106373 NZ_CP029683:55772-56053 [Salmonella sp. FORC89]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT106373 WP_000121743.1 NZ_CP029683:55531-55782 [Salmonella sp. FORC89]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT106373 NZ_CP029683:55531-55782 [Salmonella sp. FORC89]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References