Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4178974..4179755 Replicon chromosome
Accession NZ_CP029682
Organism Salmonella sp. FORC89

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag FORC89_RS20455 Protein ID WP_000626100.1
Coordinates 4178974..4179465 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag FORC89_RS20460 Protein ID WP_001110452.1
Coordinates 4179462..4179755 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC89_RS20420 (4174434) 4174434..4174781 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
FORC89_RS20425 (4174757) 4174757..4176460 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
FORC89_RS20430 (4176497) 4176497..4177072 + 576 WP_001188509.1 transcriptional regulator -
FORC89_RS20440 (4177343) 4177343..4177417 - 75 Protein_3994 helix-turn-helix domain-containing protein -
FORC89_RS20445 (4177797) 4177797..4177874 + 78 Protein_3995 porin family protein -
FORC89_RS20450 (4177974) 4177974..4178726 + 753 WP_000842433.1 non-specific acid phosphatase -
FORC89_RS20455 (4178974) 4178974..4179465 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
FORC89_RS20460 (4179462) 4179462..4179755 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
FORC89_RS20465 (4180072) 4180072..4180293 + 222 WP_001576552.1 hypothetical protein -
FORC89_RS20470 (4180559) 4180559..4181434 + 876 WP_000921676.1 AraC family transcriptional regulator -
FORC89_RS20475 (4181431) 4181431..4181718 + 288 WP_001541332.1 transcriptional regulator RtsB -
FORC89_RS20480 (4181711) 4181711..4181893 - 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
FORC89_RS20485 (4182018) 4182018..4182266 + 249 Protein_4003 Ig-like domain-containing protein -
FORC89_RS20490 (4182378) 4182378..4182509 + 132 Protein_4004 hypothetical protein -
FORC89_RS20495 (4182803) 4182803..4183708 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T106369 WP_000626100.1 NZ_CP029682:c4179465-4178974 [Salmonella sp. FORC89]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T106369 NZ_CP029682:c4179465-4178974 [Salmonella sp. FORC89]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT106369 WP_001110452.1 NZ_CP029682:c4179755-4179462 [Salmonella sp. FORC89]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT106369 NZ_CP029682:c4179755-4179462 [Salmonella sp. FORC89]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References