Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4030953..4031503 Replicon chromosome
Accession NZ_CP029682
Organism Salmonella sp. FORC89

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag FORC89_RS19670 Protein ID WP_001199743.1
Coordinates 4030953..4031261 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag FORC89_RS19675 Protein ID WP_001118105.1
Coordinates 4031264..4031503 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC89_RS19650 (4027527) 4027527..4028267 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
FORC89_RS19655 (4028389) 4028389..4028919 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
FORC89_RS19660 (4029242) 4029242..4030375 + 1134 Protein_3843 IS3 family transposase -
FORC89_RS19665 (4030407) 4030407..4030547 - 141 Protein_3844 Arm DNA-binding domain-containing protein -
FORC89_RS19670 (4030953) 4030953..4031261 - 309 WP_001199743.1 CcdB family protein Toxin
FORC89_RS19675 (4031264) 4031264..4031503 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
FORC89_RS19680 (4031612) 4031612..4031860 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
FORC89_RS19685 (4032051) 4032051..4032482 - 432 Protein_3848 helix-turn-helix domain-containing protein -
FORC89_RS19695 (4033239) 4033239..4034258 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
FORC89_RS19700 (4034286) 4034286..4034816 - 531 WP_000896758.1 gluconokinase -
FORC89_RS19705 (4035033) 4035033..4036064 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029334..4032437 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T106367 WP_001199743.1 NZ_CP029682:c4031261-4030953 [Salmonella sp. FORC89]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T106367 NZ_CP029682:c4031261-4030953 [Salmonella sp. FORC89]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT106367 WP_001118105.1 NZ_CP029682:c4031503-4031264 [Salmonella sp. FORC89]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT106367 NZ_CP029682:c4031503-4031264 [Salmonella sp. FORC89]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References