Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3986692..3987268 Replicon chromosome
Accession NZ_CP029682
Organism Salmonella sp. FORC89

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag FORC89_RS19460 Protein ID WP_001131963.1
Coordinates 3986981..3987268 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag FORC89_RS19455 Protein ID WP_000063142.1
Coordinates 3986692..3986994 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC89_RS19440 (3983202) 3983202..3985352 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
FORC89_RS19445 (3985447) 3985447..3985650 + 204 WP_000460616.1 YbdD/YjiX family protein -
FORC89_RS19450 (3985661) 3985661..3986617 + 957 WP_000187843.1 GTPase -
FORC89_RS19455 (3986692) 3986692..3986994 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
FORC89_RS19460 (3986981) 3986981..3987268 - 288 WP_001131963.1 BrnT family toxin Toxin
FORC89_RS19465 (3987685) 3987685..3988941 + 1257 Protein_3804 NERD domain-containing protein/DEAD/DEAH box helicase -
FORC89_RS19470 (3988935) 3988935..3989114 + 180 Protein_3805 DNA methyltransferase -
FORC89_RS19475 (3989104) 3989104..3990408 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T106366 WP_001131963.1 NZ_CP029682:c3987268-3986981 [Salmonella sp. FORC89]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T106366 NZ_CP029682:c3987268-3986981 [Salmonella sp. FORC89]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT106366 WP_000063142.1 NZ_CP029682:c3986994-3986692 [Salmonella sp. FORC89]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT106366 NZ_CP029682:c3986994-3986692 [Salmonella sp. FORC89]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References