Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411299..3411919 Replicon chromosome
Accession NZ_CP029682
Organism Salmonella sp. FORC89

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag FORC89_RS16810 Protein ID WP_001280991.1
Coordinates 3411701..3411919 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag FORC89_RS16805 Protein ID WP_000344807.1
Coordinates 3411299..3411673 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC89_RS16795 (3406438) 3406438..3407631 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FORC89_RS16800 (3407654) 3407654..3410803 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
FORC89_RS16805 (3411299) 3411299..3411673 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
FORC89_RS16810 (3411701) 3411701..3411919 + 219 WP_001280991.1 HHA domain-containing protein Toxin
FORC89_RS16815 (3412098) 3412098..3412649 + 552 WP_001278793.1 maltose O-acetyltransferase -
FORC89_RS16820 (3412767) 3412767..3413237 + 471 WP_000136183.1 YlaC family protein -
FORC89_RS16825 (3413293) 3413293..3413433 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
FORC89_RS16830 (3413439) 3413439..3413699 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
FORC89_RS16835 (3413924) 3413924..3415474 + 1551 WP_000213140.1 EAL domain-containing protein -
FORC89_RS16845 (3415705) 3415705..3416094 + 390 WP_000961287.1 MGMT family protein -
FORC89_RS16850 (3416127) 3416127..3416696 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T106362 WP_001280991.1 NZ_CP029682:3411701-3411919 [Salmonella sp. FORC89]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T106362 NZ_CP029682:3411701-3411919 [Salmonella sp. FORC89]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT106362 WP_000344807.1 NZ_CP029682:3411299-3411673 [Salmonella sp. FORC89]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT106362 NZ_CP029682:3411299-3411673 [Salmonella sp. FORC89]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References