Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835878..836503 Replicon chromosome
Accession NZ_CP029682
Organism Salmonella sp. FORC89

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag FORC89_RS04035 Protein ID WP_000911336.1
Coordinates 836105..836503 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag FORC89_RS04030 Protein ID WP_000557549.1
Coordinates 835878..836105 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC89_RS04000 (830886) 830886..832403 + 1518 WP_000003339.1 lysine--tRNA ligase -
FORC89_RS04005 (832479) 832479..833024 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
FORC89_RS04010 (833289) 833289..834047 + 759 WP_000244328.1 amidase activator ActS -
FORC89_RS04020 (834332) 834332..835138 - 807 WP_001574939.1 DUF1460 domain-containing protein -
FORC89_RS04025 (835418) 835418..835669 - 252 WP_001576352.1 hypothetical protein -
FORC89_RS04030 (835878) 835878..836105 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
FORC89_RS04035 (836105) 836105..836503 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
FORC89_RS04040 (837311) 837311..837847 + 537 WP_001038502.1 STM3031 family outer membrane protein -
FORC89_RS04045 (837894) 837894..838526 + 633 WP_000835265.1 YfdX family protein -
FORC89_RS04050 (839245) 839245..839826 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 834332..845687 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T106350 WP_000911336.1 NZ_CP029682:836105-836503 [Salmonella sp. FORC89]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T106350 NZ_CP029682:836105-836503 [Salmonella sp. FORC89]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT106350 WP_000557549.1 NZ_CP029682:835878-836105 [Salmonella sp. FORC89]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT106350 NZ_CP029682:835878-836105 [Salmonella sp. FORC89]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References