Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824954..825614 Replicon chromosome
Accession NZ_CP029682
Organism Salmonella sp. FORC89

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag FORC89_RS03970 Protein ID WP_000244756.1
Coordinates 825201..825614 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag FORC89_RS03965 Protein ID WP_000351186.1
Coordinates 824954..825220 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC89_RS03945 (820883) 820883..822316 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
FORC89_RS03950 (822474) 822474..822785 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
FORC89_RS03955 (822949) 822949..823608 + 660 WP_000250289.1 hemolysin III family protein -
FORC89_RS03960 (823724) 823724..824704 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
FORC89_RS03965 (824954) 824954..825220 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
FORC89_RS03970 (825201) 825201..825614 + 414 WP_000244756.1 protein YgfX Toxin
FORC89_RS03975 (825667) 825667..826188 - 522 WP_001055885.1 flavodoxin FldB -
FORC89_RS03980 (826301) 826301..827197 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
FORC89_RS03985 (827221) 827221..827934 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FORC89_RS03990 (827940) 827940..829673 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T106349 WP_000244756.1 NZ_CP029682:825201-825614 [Salmonella sp. FORC89]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T106349 NZ_CP029682:825201-825614 [Salmonella sp. FORC89]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT106349 WP_000351186.1 NZ_CP029682:824954-825220 [Salmonella sp. FORC89]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT106349 NZ_CP029682:824954-825220 [Salmonella sp. FORC89]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References